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- W2018336835 abstract "Coronaridine [1], conoduramine [2], and voacamine [3], three indole alkaloids isolated from Peschiera laeta, have been found to enhance the cytotoxic response mediated by vinblastine [4] with multidrug-resistant KB cells. Inhibition of vinblastine binding with membrane vesicles isolated from this cell line was also assessed, and the bisindole alkaloids conoduramine [2] and voacamine [3] were found to be more potent inhibitory agents than the monomeric alkaloid, coronaridine [1]. Thus, these compounds appear to function by binding with P-glycoprotein." @default.
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- W2018336835 date "1994-11-01" @default.
- W2018336835 modified "2023-09-26" @default.
- W2018336835 title "Indole Alkaloids from Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity with Multi-drug-Resistant Cells" @default.
- W2018336835 doi "https://doi.org/10.1021/np50113a007" @default.
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