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- W2018339172 abstract "Purpose: With the widespread use of ionising radiation, the risks of low-dose radiation have been increasingly highlighted for special attention. This review introduces the potential role of epigenetic elements in the regulation of the effects of low-dose radiation.Materials and methods: The related literature has been analysed according to the topics of DNA methylation, histone modifications, chromatin remodelling and non-coding RNA modulation in low-dose radiation responses.Results: DNA methylation and radiation can reciprocally regulate effects, especially in the low-dose radiation area. The relationship between histone methylation and radiation mainly exists in the high-dose radiation area; histone deacetylase inhibitors show a promising application to enhance radiation sensitivity, both in the low-dose and high-dose areas; phosphorylated histone 2 AX (H2AX) shows a low sensitivity with 1–15 Gy irradiation as compared with lower dose radiation; and histone ubiquitination plays an important role in DNA damage repair mechanisms. Moreover, chromatin remodelling has an integral role in the repair of DNA double-strand breaks and the response of chromatin to ionising radiation. Finally, the effect of radiation on microRNA expression seems to vary according to cell type, radiation dose, and post-irradiation time point.Conclusion: Small advances have been made in the understanding of epigenetic regulation of low-dose radiation responses. Many questions and blind spots deserve to be investigated. Many new epigenetic elements will be identified in low-dose radiation responses, which may give new insights into the mechanisms of radiation response and their exploitation in radiotherapy." @default.
- W2018339172 created "2016-06-24" @default.
- W2018339172 creator A5006543439 @default.
- W2018339172 creator A5021687717 @default.
- W2018339172 creator A5035168940 @default.
- W2018339172 creator A5037297411 @default.
- W2018339172 creator A5082082145 @default.
- W2018339172 date "2010-06-15" @default.
- W2018339172 modified "2023-10-16" @default.
- W2018339172 title "Low-dose radiation-induced responses: Focusing on epigenetic regulation" @default.
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