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• W2018343899 abstract "Treatment of rat mesangial cells with interleukin 1β (IL‐1β) and forskolin greatly enhanced the expression of group II phospholipase A 2 (PLA 2 ) mRNA, with subsequent increased synthesis and secretion of PLA 2 as detected by PLA 2 activity measurements and immunoprecipitation of culture media of [ 35 S]methionine‐labelled mesangial cells. PDGF—BB dose‐dependently suppressed the IL‐1β‐ and forskolin‐induced elevation of PLA 2 mRNA, as well as PLA 2 synthesis and secretion. In contrast, PDGF—AA had no inhibitory effect. The tyrosine kinase inhibitor genistein dose‐dependently antagonized the inhibitory effect of PDGF‐BB on IL‐1β‐stimulated PLA 2 secretion, thus suggesting that tyrosine phosphorylation may be required for PDGF‐BB inhibition of PLA 2 gene expression in mesangial cells." @default.
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• W2018343899 date "1991-10-21" @default.
• W2018343899 modified "2023-10-16" @default.
• W2018343899 title "PDGF suppresses the activation of group II phospholipase A₂gene expression by interleukin I and forskolin in mesangial cells" @default.
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• W2018343899 doi "https://doi.org/10.1016/0014-5793(91)81295-j" @default.
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