FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018345997> ?p ?o ?g. }

• W2018345997 endingPage "116" @default.
• W2018345997 startingPage "111" @default.
• W2018345997 abstract "Although a number of studies have shown that perivascular adipose tissue (PVAT) attenuates arterial contraction through the release of perivascular-derived relaxation factors (PVRF), the role of PVAT in modulating venous function and its mechanism(s) remained unknown. Here we examined the role of PVAT in the modulation of vascular function in the inferior vena cava. Venous rings from male Wistar rats were prepared with both endothelium and PVAT intact, with either PVAT or endothelium removed, or with both endothelium and PVAT removed for functional studies. Contractile response to phenylephrine, U 46619, or 5-hydroxytryptamine was significantly attenuated in PVAT+ as compared with PVAT− veins. PVAT− vessels with intact endothelium (E+) pre-contracted with phenylephrine showed a concentration-dependent relaxation response to angiotensin 1–7 [Ang-(1–7)], and this response was abolished by the removal of endothelium, and by Ang-(1–7) (Mas) receptor antagonists D-Ala-Ang-(1–7) (A779) or D-Pro7-Ang-(1–7). Donor solution incubated with a PVAT+ ring induced a relaxation response in the E+ recipient vessel but not in E− recipient vessel. The use of specific channel blockers and enzyme inhibitors showed that Ang-(1–7) is a transferable PVRF that induces endothelium-dependent relaxation through NO release and activation of voltage-dependent potassium (K+) channels (Kv) channels. We conclude that venous PVAT attenuates agonist-induced contraction by releasing Ang-(1–7), which causes relaxation of smooth muscle through endothelial NO release and activation of Kv channels." @default.
• W2018345997 created "2016-06-24" @default.
• W2018345997 creator A5010006464 @default.
• W2018345997 creator A5027627332 @default.
• W2018345997 creator A5044847603 @default.
• W2018345997 creator A5062960911 @default.
• W2018345997 date "2011-04-01" @default.
• W2018345997 modified "2023-09-23" @default.
• W2018345997 title "Modulation of vein function by perivascular adipose tissue" @default.
• W2018345997 cites W1983404645 @default.
• W2018345997 cites W1998856849 @default.
• W2018345997 cites W2004452702 @default.
• W2018345997 cites W2013517541 @default.
• W2018345997 cites W2027480261 @default.
• W2018345997 cites W2027494269 @default.
• W2018345997 cites W2057647317 @default.
• W2018345997 cites W2066590292 @default.
• W2018345997 cites W2091723963 @default.
• W2018345997 cites W2134328477 @default.
• W2018345997 cites W2151022783 @default.
• W2018345997 cites W2152809661 @default.
• W2018345997 cites W2155676403 @default.
• W2018345997 cites W2158634745 @default.
• W2018345997 cites W2162591441 @default.
• W2018345997 cites W2171288078 @default.
• W2018345997 cites W2171905844 @default.
• W2018345997 doi "https://doi.org/10.1016/j.ejphar.2010.12.028" @default.
• W2018345997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21236250" @default.
• W2018345997 hasPublicationYear "2011" @default.
• W2018345997 type Work @default.
• W2018345997 sameAs 2018345997 @default.
• W2018345997 citedByCount "43" @default.
• W2018345997 countsByYear W20183459972012 @default.
• W2018345997 countsByYear W20183459972013 @default.
• W2018345997 countsByYear W20183459972014 @default.
• W2018345997 countsByYear W20183459972015 @default.
• W2018345997 countsByYear W20183459972016 @default.
• W2018345997 countsByYear W20183459972017 @default.
• W2018345997 countsByYear W20183459972018 @default.
• W2018345997 countsByYear W20183459972019 @default.
• W2018345997 countsByYear W20183459972020 @default.
• W2018345997 countsByYear W20183459972021 @default.
• W2018345997 countsByYear W20183459972023 @default.
• W2018345997 crossrefType "journal-article" @default.
• W2018345997 hasAuthorship W2018345997A5010006464 @default.
• W2018345997 hasAuthorship W2018345997A5027627332 @default.
• W2018345997 hasAuthorship W2018345997A5044847603 @default.
• W2018345997 hasAuthorship W2018345997A5062960911 @default.
• W2018345997 hasConcept C126322002 @default.
• W2018345997 hasConcept C134018914 @default.
• W2018345997 hasConcept C163415756 @default.
• W2018345997 hasConcept C170493617 @default.
• W2018345997 hasConcept C171089720 @default.
• W2018345997 hasConcept C185592680 @default.
• W2018345997 hasConcept C202751555 @default.
• W2018345997 hasConcept C2776992346 @default.
• W2018345997 hasConcept C2777411675 @default.
• W2018345997 hasConcept C2777952589 @default.
• W2018345997 hasConcept C2778938600 @default.
• W2018345997 hasConcept C2779395532 @default.
• W2018345997 hasConcept C2992686903 @default.
• W2018345997 hasConcept C55493867 @default.
• W2018345997 hasConcept C71924100 @default.
• W2018345997 hasConcept C84393581 @default.
• W2018345997 hasConceptScore W2018345997C126322002 @default.
• W2018345997 hasConceptScore W2018345997C134018914 @default.
• W2018345997 hasConceptScore W2018345997C163415756 @default.
• W2018345997 hasConceptScore W2018345997C170493617 @default.
• W2018345997 hasConceptScore W2018345997C171089720 @default.
• W2018345997 hasConceptScore W2018345997C185592680 @default.
• W2018345997 hasConceptScore W2018345997C202751555 @default.
• W2018345997 hasConceptScore W2018345997C2776992346 @default.
• W2018345997 hasConceptScore W2018345997C2777411675 @default.
• W2018345997 hasConceptScore W2018345997C2777952589 @default.
• W2018345997 hasConceptScore W2018345997C2778938600 @default.
• W2018345997 hasConceptScore W2018345997C2779395532 @default.
• W2018345997 hasConceptScore W2018345997C2992686903 @default.
• W2018345997 hasConceptScore W2018345997C55493867 @default.
• W2018345997 hasConceptScore W2018345997C71924100 @default.
• W2018345997 hasConceptScore W2018345997C84393581 @default.
• W2018345997 hasIssue "1-3" @default.
• W2018345997 hasLocation W20183459971 @default.
• W2018345997 hasLocation W20183459972 @default.
• W2018345997 hasOpenAccess W2018345997 @default.
• W2018345997 hasPrimaryLocation W20183459971 @default.
• W2018345997 hasRelatedWork W1964688190 @default.
• W2018345997 hasRelatedWork W1978718098 @default.
• W2018345997 hasRelatedWork W2017606817 @default.
• W2018345997 hasRelatedWork W2027098794 @default.
• W2018345997 hasRelatedWork W2049045125 @default.
• W2018345997 hasRelatedWork W2071032213 @default.
• W2018345997 hasRelatedWork W2081564223 @default.
• W2018345997 hasRelatedWork W2167541966 @default.
• W2018345997 hasRelatedWork W2748952813 @default.
• W2018345997 hasRelatedWork W4253482381 @default.
• W2018345997 hasVolume "657" @default.
• W2018345997 isParatext "false" @default.
• W2018345997 isRetracted "false" @default.

• next