FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018355587> ?p ?o ?g. }

• W2018355587 endingPage "19" @default.
• W2018355587 startingPage "11" @default.
• W2018355587 abstract "The structure of TPK1Δ, a truncated variant of the cAMP-dependent protein kinase catalytic subunit from Saccharomyces cerevisiae, was determined in an unliganded state at 2.8 Å resolution and refined to a crystallographic R-factor of 19.4%. Comparison of this structure to that of its fully liganded mammalian homolog revealed a highly conserved protein fold comprised of two globular lobes. Within each lobe, root mean square deviations in Cα positions averaged ≈0.9 Å. In addition, a phosphothreonine residue was found in the C-terminal domain of each enzyme. Further comparison of the two structures suggests that a trio of conformational changes accompanies ligand-binding. The first consists of a 14.7° rigid-body rotation of one lobe relative to the other and results in closure of the active site cleft. The second affects only the glycine-rich nucleotide binding loop, which moves ≈3 Å to further close the active site and traps the nucleotide substrate. The third is localized to a C-terminal segment that makes direct contact with ligands and the ligand-binding cleft. In addition to resolving the conformation of unliganded enzyme, the model shows that the salient features of the cAMP-dependent protein kinase are conserved over long evolutionary distances." @default.
• W2018355587 created "2016-06-24" @default.
• W2018355587 creator A5000871276 @default.
• W2018355587 creator A5004840529 @default.
• W2018355587 creator A5008670603 @default.
• W2018355587 creator A5056167592 @default.
• W2018355587 date "2001-03-01" @default.
• W2018355587 modified "2023-10-18" @default.
• W2018355587 title "Structure of the Unliganded cAMP-Dependent Protein Kinase Catalytic Subunit from Saccharomyces cerevisiae" @default.
• W2018355587 cites W1014698510 @default.
• W2018355587 cites W1484221662 @default.
• W2018355587 cites W1499956845 @default.
• W2018355587 cites W1508885706 @default.
• W2018355587 cites W1565601414 @default.
• W2018355587 cites W1568303936 @default.
• W2018355587 cites W1571992686 @default.
• W2018355587 cites W1598635760 @default.
• W2018355587 cites W1600771042 @default.
• W2018355587 cites W1603300564 @default.
• W2018355587 cites W1941291890 @default.
• W2018355587 cites W194357103 @default.
• W2018355587 cites W1977983845 @default.
• W2018355587 cites W1986191025 @default.
• W2018355587 cites W1991445188 @default.
• W2018355587 cites W1995017064 @default.
• W2018355587 cites W1996607909 @default.
• W2018355587 cites W1998140488 @default.
• W2018355587 cites W2001206945 @default.
• W2018355587 cites W2003431879 @default.
• W2018355587 cites W2008708467 @default.
• W2018355587 cites W2010708479 @default.
• W2018355587 cites W2015956088 @default.
• W2018355587 cites W2042314648 @default.
• W2018355587 cites W2046533734 @default.
• W2018355587 cites W2049902088 @default.
• W2018355587 cites W2056261986 @default.
• W2018355587 cites W2067405360 @default.
• W2018355587 cites W2067768607 @default.
• W2018355587 cites W2069049326 @default.
• W2018355587 cites W2072098108 @default.
• W2018355587 cites W2089291239 @default.
• W2018355587 cites W2095869995 @default.
• W2018355587 cites W2108174107 @default.
• W2018355587 cites W2110847661 @default.
• W2018355587 cites W2117514600 @default.
• W2018355587 cites W2119694628 @default.
• W2018355587 cites W2125493548 @default.
• W2018355587 cites W2125992177 @default.
• W2018355587 cites W2128859932 @default.
• W2018355587 cites W2154143571 @default.
• W2018355587 cites W2226038589 @default.
• W2018355587 doi "https://doi.org/10.1006/abbi.2000.2241" @default.
• W2018355587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11368172" @default.
• W2018355587 hasPublicationYear "2001" @default.
• W2018355587 type Work @default.
• W2018355587 sameAs 2018355587 @default.
• W2018355587 citedByCount "14" @default.
• W2018355587 countsByYear W20183555872019 @default.
• W2018355587 countsByYear W20183555872020 @default.
• W2018355587 countsByYear W20183555872021 @default.
• W2018355587 countsByYear W20183555872022 @default.
• W2018355587 crossrefType "journal-article" @default.
• W2018355587 hasAuthorship W2018355587A5000871276 @default.
• W2018355587 hasAuthorship W2018355587A5004840529 @default.
• W2018355587 hasAuthorship W2018355587A5008670603 @default.
• W2018355587 hasAuthorship W2018355587A5056167592 @default.
• W2018355587 hasConcept C104292427 @default.
• W2018355587 hasConcept C104317684 @default.
• W2018355587 hasConcept C107824862 @default.
• W2018355587 hasConcept C116569031 @default.
• W2018355587 hasConcept C12554922 @default.
• W2018355587 hasConcept C170493617 @default.
• W2018355587 hasConcept C181199279 @default.
• W2018355587 hasConcept C185592680 @default.
• W2018355587 hasConcept C2777576037 @default.
• W2018355587 hasConcept C2779222958 @default.
• W2018355587 hasConcept C41183919 @default.
• W2018355587 hasConcept C47701112 @default.
• W2018355587 hasConcept C55493867 @default.
• W2018355587 hasConcept C71240020 @default.
• W2018355587 hasConcept C8010536 @default.
• W2018355587 hasConcept C86803240 @default.
• W2018355587 hasConceptScore W2018355587C104292427 @default.
• W2018355587 hasConceptScore W2018355587C104317684 @default.
• W2018355587 hasConceptScore W2018355587C107824862 @default.
• W2018355587 hasConceptScore W2018355587C116569031 @default.
• W2018355587 hasConceptScore W2018355587C12554922 @default.
• W2018355587 hasConceptScore W2018355587C170493617 @default.
• W2018355587 hasConceptScore W2018355587C181199279 @default.
• W2018355587 hasConceptScore W2018355587C185592680 @default.
• W2018355587 hasConceptScore W2018355587C2777576037 @default.
• W2018355587 hasConceptScore W2018355587C2779222958 @default.
• W2018355587 hasConceptScore W2018355587C41183919 @default.
• W2018355587 hasConceptScore W2018355587C47701112 @default.
• W2018355587 hasConceptScore W2018355587C55493867 @default.
• W2018355587 hasConceptScore W2018355587C71240020 @default.
• W2018355587 hasConceptScore W2018355587C8010536 @default.
• W2018355587 hasConceptScore W2018355587C86803240 @default.

• next