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- W2018356085 abstract "1. The influence of 6-azauracil on metabolism of 14C-labeled orotic acid and uracil was studied in leaf discs of the cocklebur plant, Xanthium pennsylvanicum Wall. 2. Conversion of orotic acid to ribonucleic acid was inhibited by azauracil. Considerable evidence indicates an interference with decarboxylation of orotidylic acid: CO2 release from [carboxy-14C]orotic acid was reduced by an amount approximately equal to the inhibition of ribonucleic acid synthesis from [2-14C]orotic acid. Under these conditions orotic acid accumulated in the cells. Synthesis of ribonucleic acid from labeled uracil was not reduced, provided corrections were made for inhibition of uracil absorption into the leaf discs by azauracil. 3. 12 metabolites of uracil were detected in hot ethanol (80%) extracts of the tissues, including the catabolic products dihydrouracil and β-ureidopropionic acid. Certain uridine nucleotides were also present. Azauracil inhibited conversion of uracil into a nucleotide tentatively identified as uridine-diphosphate glucose. 4. Orotidylic acid and orotidine were not present in the leaves in amounts detectable by the techniques used." @default.
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- W2018356085 date "1964-08-01" @default.
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- W2018356085 title "Influence of 6-azauracil on pyrimidine metabolism of cocklebur leaf discs" @default.
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- W2018356085 doi "https://doi.org/10.1016/0926-6550(64)90274-9" @default.
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