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- W2018357257 abstract "Metoprolol CR/ZOK (controlled release, zero order kinetics) is a new formulation of an extensively used β1-selective, β-adrenoceptor blocking drug, (β1,-blocker), designed to provide continuous, even, plasma concentrations in the therapeutic range. It should, therefore, provide an effective well-tolerated treatment for hypertension and angina pectoris and for use in secondary prevention following a myocardial infarct. The purpose of this review is to consider the need for such a formulation, to describe its pharmaceutical development, review its pharmacology and assess its efficacy and tolerability compared with other available agents." @default.
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- W2018357257 date "1989-06-01" @default.
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- W2018357257 title "METOPROLOL—CONTROLLED RELEASE, ZERO ORDER KINETICS" @default.
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- W2018357257 doi "https://doi.org/10.1111/j.1365-2710.1989.tb00235.x" @default.
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