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• W2018358410 abstract "Many principal neurons undergo an early developmental switch from GluR2-lacking to GluR2-containing synaptic glutamate receptors. We tested the generality and timing of the GluR2 switch in excitatory neurons of rat somatosensory cortex. Previous studies show that the switch occurs between postnatal day 14 (P14) and P16 in layer 5 pyramidal neurons. We show, using sensitivity to intracellular spermine, that a similar switch occurs between P12 and P14 in layer 2/3 pyramidal cells and between P7 and P8 in layer 4 stellate cells. The presence of GluR2-lacking receptors in layer 2/3 pyramidal cells before P12 was confirmed by demonstrating sensitivity to blockade by 1-naphthyl-acetyl-spermine and large single-channel conductances. GluR2 and the postsynaptic protein PSD95 show progressive colocalization in tissue from P10, P14, and P24 rats, mirroring electrophysiological developments. To distinguish whether changes in GluR2 expression or targeting underlie the switch, we characterized dendritic AMPA receptor responses using focal photolysis of caged glutamate. Contrary to synaptic responses, dendritic responses at all ages studied (P6–P40) were characteristic of GluR2-containing receptors. In addition, dendritically and synaptically evoked responses showed a corresponding decrease in NMDA/AMPA ratios in pyramidal cells, suggesting parallel mechanisms that regulate neuronal calcium levels. These data suggest that the GluR2 switch results from changes in AMPA receptor targeting during early postnatal development, and that rather than following the laminar sequence of cortical development, it proceeds sequentially from layer 4 to layer 2/3 and finally to layer 5b." @default.
• W2018358410 created "2016-06-24" @default.
• W2018358410 creator A5033400284 @default.
• W2018358410 creator A5043663159 @default.
• W2018358410 date "2008-12-17" @default.
• W2018358410 modified "2023-10-16" @default.
• W2018358410 title "Sequential Changes in AMPA Receptor Targeting in the Developing Neocortical Excitatory Circuit" @default.
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• W2018358410 doi "https://doi.org/10.1523/jneurosci.3229-08.2008" @default.
• W2018358410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2706010" @default.
• W2018358410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19091980" @default.
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