FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018362808> ?p ?o ?g. }

• W2018362808 endingPage "155" @default.
• W2018362808 startingPage "147" @default.
• W2018362808 abstract "1. The group II metabotropic glutamate (mGlu) receptor antagonist (2S,1'S,2'S)-2-(2-carboxycyclopropyl)-2-(9H-xanthen-9-yl)glycine (LY341495) also has activity at group I and III mGlu receptors at higher concentrations and can be used to discriminate between mGlu receptor subtypes. We report the antagonist action of LY341495 on glutamate receptors expressed in the neonatal rat spinal cord preparation and the use of this antagonist to investigate the group III mGlu receptor subtypes responsible for mediating the depression of synaptic transmission in the spinal cord mediated by the group III mGlu receptor agonists (S)-2-amino-4-phosphonobutanoic acid ((S)-AP4) and (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid (ACPT-I). 2. LY341495 antagonised mGlu receptor agonist-induced responses in the spinal cord with a rank order of potency of group II > group III > group I, which is the same as that observed in human cloned mGlu receptor cell lines. Antagonism of group II and III mGlu receptor-mediated effects were time dependent when low-nanomolar concentrations of LY341495 were used. Although the rank order of potency of LY341495 was the same on native rat and cloned human mGlu receptors, there was a compression in the selectivity between group II and III mGlu receptors, expressed in the spinal cord. 3. In agreement with a previous study on cloned ionotropic glutamate receptors 100 microM LY341495 had little or no effect on N-methyl-D-aspartate, (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid or kainate receptor-mediated responses on motoneurones. 4. LY341495 exhibited low-nanomolar potency antagonist activity against (S)-AP4 and ACPT-I suggesting that these agonists are activating predominantly mGlu8 and that mGlu4 receptors do not play a role in modulating synaptic transmission in the pathways stimulated in the experiments described here." @default.
• W2018362808 created "2016-06-24" @default.
• W2018362808 creator A5002091267 @default.
• W2018362808 creator A5042941039 @default.
• W2018362808 date "2003-05-01" @default.
• W2018362808 modified "2023-10-14" @default.
• W2018362808 title "Actions of LY341495 on metabotropic glutamate receptor-mediated responses in the neonatal rat spinal cord" @default.
• W2018362808 cites W1810764863 @default.
• W2018362808 cites W1975317646 @default.
• W2018362808 cites W1977098380 @default.
• W2018362808 cites W1980847901 @default.
• W2018362808 cites W1987836761 @default.
• W2018362808 cites W1990846257 @default.
• W2018362808 cites W1999259477 @default.
• W2018362808 cites W2004668023 @default.
• W2018362808 cites W2006958480 @default.
• W2018362808 cites W2011880474 @default.
• W2018362808 cites W2016413308 @default.
• W2018362808 cites W2029542833 @default.
• W2018362808 cites W2043166209 @default.
• W2018362808 cites W2052115812 @default.
• W2018362808 cites W2053386531 @default.
• W2018362808 cites W2057776188 @default.
• W2018362808 cites W2067795636 @default.
• W2018362808 cites W2069338515 @default.
• W2018362808 cites W2078199061 @default.
• W2018362808 cites W2079388530 @default.
• W2018362808 cites W2080529726 @default.
• W2018362808 cites W2081831423 @default.
• W2018362808 cites W2083650471 @default.
• W2018362808 cites W2091281983 @default.
• W2018362808 cites W2091730749 @default.
• W2018362808 cites W2094635422 @default.
• W2018362808 cites W2170146962 @default.
• W2018362808 cites W2180941170 @default.
• W2018362808 cites W2254502236 @default.
• W2018362808 cites W2951764089 @default.
• W2018362808 doi "https://doi.org/10.1038/sj.bjp.0705230" @default.
• W2018362808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573828" @default.
• W2018362808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12746233" @default.
• W2018362808 hasPublicationYear "2003" @default.
• W2018362808 type Work @default.
• W2018362808 sameAs 2018362808 @default.
• W2018362808 citedByCount "6" @default.
• W2018362808 countsByYear W20183628082018 @default.
• W2018362808 countsByYear W20183628082020 @default.
• W2018362808 crossrefType "journal-article" @default.
• W2018362808 hasAuthorship W2018362808A5002091267 @default.
• W2018362808 hasAuthorship W2018362808A5042941039 @default.
• W2018362808 hasBestOaLocation W20183628082 @default.
• W2018362808 hasConcept C116592611 @default.
• W2018362808 hasConcept C119128870 @default.
• W2018362808 hasConcept C126322002 @default.
• W2018362808 hasConcept C170493617 @default.
• W2018362808 hasConcept C200385062 @default.
• W2018362808 hasConcept C207951395 @default.
• W2018362808 hasConcept C26702167 @default.
• W2018362808 hasConcept C2778938600 @default.
• W2018362808 hasConcept C41653306 @default.
• W2018362808 hasConcept C49051014 @default.
• W2018362808 hasConcept C55493867 @default.
• W2018362808 hasConcept C61174792 @default.
• W2018362808 hasConcept C71924100 @default.
• W2018362808 hasConcept C86803240 @default.
• W2018362808 hasConcept C87247309 @default.
• W2018362808 hasConcept C98274493 @default.
• W2018362808 hasConceptScore W2018362808C116592611 @default.
• W2018362808 hasConceptScore W2018362808C119128870 @default.
• W2018362808 hasConceptScore W2018362808C126322002 @default.
• W2018362808 hasConceptScore W2018362808C170493617 @default.
• W2018362808 hasConceptScore W2018362808C200385062 @default.
• W2018362808 hasConceptScore W2018362808C207951395 @default.
• W2018362808 hasConceptScore W2018362808C26702167 @default.
• W2018362808 hasConceptScore W2018362808C2778938600 @default.
• W2018362808 hasConceptScore W2018362808C41653306 @default.
• W2018362808 hasConceptScore W2018362808C49051014 @default.
• W2018362808 hasConceptScore W2018362808C55493867 @default.
• W2018362808 hasConceptScore W2018362808C61174792 @default.
• W2018362808 hasConceptScore W2018362808C71924100 @default.
• W2018362808 hasConceptScore W2018362808C86803240 @default.
• W2018362808 hasConceptScore W2018362808C87247309 @default.
• W2018362808 hasConceptScore W2018362808C98274493 @default.
• W2018362808 hasIssue "1" @default.
• W2018362808 hasLocation W20183628081 @default.
• W2018362808 hasLocation W20183628082 @default.
• W2018362808 hasLocation W20183628083 @default.
• W2018362808 hasLocation W20183628084 @default.
• W2018362808 hasOpenAccess W2018362808 @default.
• W2018362808 hasPrimaryLocation W20183628081 @default.
• W2018362808 hasRelatedWork W2005377718 @default.
• W2018362808 hasRelatedWork W2022990675 @default.
• W2018362808 hasRelatedWork W2079873749 @default.
• W2018362808 hasRelatedWork W2093341222 @default.
• W2018362808 hasRelatedWork W2161584310 @default.
• W2018362808 hasRelatedWork W2603012921 @default.
• W2018362808 hasRelatedWork W4214714366 @default.
• W2018362808 hasRelatedWork W82560567 @default.
• W2018362808 hasRelatedWork W2673294575 @default.

• next