FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018367487> ?p ?o ?g. }

• W2018367487 endingPage "716" @default.
• W2018367487 startingPage "709" @default.
• W2018367487 abstract "This experimental study was initiated to determine whether transmyocardial laser revascularization (TMLR) after acute myocardial ischemia may improve clinical chemistry and diminish the amount of necrosis. In addition, the influence of TMLR on healthy myocardium was analyzed.The prolonged short-term effectiveness of TMLR was evaluated in 44 open-chest anesthetized pigs with (n = 21) or without (n = 23) the setting of acute myocardial ischemia (observation period 6 h): seven pigs served as controls (thoracotomy only). An additional seven pigs had left anterior descending artery (LAD) occlusion only (ischemia group). A subsequent 14 pigs were treated by TMLR (CO2) prior to LAD occlusion: Seven pigs received one laser channel/cm2 (group 1) and in seven pigs two channels/cm2 in the LAD territory (group 2) were performed. In addition, 16 pigs underwent TMLR without ischemia: Eight pigs received one channel/cm2 (group 3) and eight pigs two channels/cm2 (group 4). Clinical chemistry, histo-chemical assessment and histology were performed.TMLR limits the expansion of the myocardial infarction zone: laser group 2 indicated a significant smaller area of necrosis in the area at risk (ischemic group (31%) vs. laser group 1 (19%), P = ns; laser group 2 (7%) vs. ischemic group, P < 0.01; laser group 1 vs. 2, P < 0.01). The amount of the area of necrosis and ischemia of laser groups 3 and 4 compared with control did not differ significantly (P = ns). Preventive creation of microchannels before ischemia did not diminish ischemic parameters (P = ns). The myocardial water content-measurements (MWC) in the ischemia, laser 1 and 2 groups did not show any difference at the end of the experiment, except higher values of laser group 2 (P < 0.05). Laser groups 3 and 4 revealed significantly higher MWC values compared with control (P < 0.001).This prolonged acute study demonstrates that CO2-TMLR significantly reduces the amount of necrosis in the area at risk, but does not reduce cardiac ischemic markers. In healthy myocardium, TMLR significantly increases myocardial water content and ischemic parameters and induces small ischemic and very small necrotic areas surrounding open laser channels. Generally, the elevated cardiac enzymes and proteins are mainly attributed to the expected rise caused by vaporization of myocardial tissue in all laser groups." @default.
• W2018367487 created "2016-06-24" @default.
• W2018367487 creator A5015795559 @default.
• W2018367487 creator A5015870166 @default.
• W2018367487 creator A5066162295 @default.
• W2018367487 creator A5066825319 @default.
• W2018367487 creator A5068322188 @default.
• W2018367487 creator A5079139834 @default.
• W2018367487 creator A5085742591 @default.
• W2018367487 creator A5086804494 @default.
• W2018367487 date "1999-05-01" @default.
• W2018367487 modified "2023-09-27" @default.
• W2018367487 title "Analysis of the new indirect revascularization method by determining objective parameters of clinical chemistry, histo-chemistry and histology" @default.
• W2018367487 cites W1978220640 @default.
• W2018367487 cites W1986214440 @default.
• W2018367487 cites W1991117742 @default.
• W2018367487 cites W1998698950 @default.
• W2018367487 cites W2005510753 @default.
• W2018367487 cites W2017320135 @default.
• W2018367487 cites W2017424364 @default.
• W2018367487 cites W2024908748 @default.
• W2018367487 cites W2031224374 @default.
• W2018367487 cites W2034915438 @default.
• W2018367487 cites W2093136190 @default.
• W2018367487 cites W2114232255 @default.
• W2018367487 cites W2125898156 @default.
• W2018367487 cites W2161456369 @default.
• W2018367487 cites W2164223534 @default.
• W2018367487 cites W2411627375 @default.
• W2018367487 cites W2424621844 @default.
• W2018367487 cites W2462255132 @default.
• W2018367487 doi "https://doi.org/10.1016/s1010-7940(99)00056-1" @default.
• W2018367487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10386422" @default.
• W2018367487 hasPublicationYear "1999" @default.
• W2018367487 type Work @default.
• W2018367487 sameAs 2018367487 @default.
• W2018367487 citedByCount "6" @default.
• W2018367487 crossrefType "journal-article" @default.
• W2018367487 hasAuthorship W2018367487A5015795559 @default.
• W2018367487 hasAuthorship W2018367487A5015870166 @default.
• W2018367487 hasAuthorship W2018367487A5066162295 @default.
• W2018367487 hasAuthorship W2018367487A5066825319 @default.
• W2018367487 hasAuthorship W2018367487A5068322188 @default.
• W2018367487 hasAuthorship W2018367487A5079139834 @default.
• W2018367487 hasAuthorship W2018367487A5085742591 @default.
• W2018367487 hasAuthorship W2018367487A5086804494 @default.
• W2018367487 hasConcept C126322002 @default.
• W2018367487 hasConcept C126894567 @default.
• W2018367487 hasConcept C164705383 @default.
• W2018367487 hasConcept C2776268601 @default.
• W2018367487 hasConcept C2779464278 @default.
• W2018367487 hasConcept C3017461755 @default.
• W2018367487 hasConcept C500558357 @default.
• W2018367487 hasConcept C503630168 @default.
• W2018367487 hasConcept C541997718 @default.
• W2018367487 hasConcept C71924100 @default.
• W2018367487 hasConceptScore W2018367487C126322002 @default.
• W2018367487 hasConceptScore W2018367487C126894567 @default.
• W2018367487 hasConceptScore W2018367487C164705383 @default.
• W2018367487 hasConceptScore W2018367487C2776268601 @default.
• W2018367487 hasConceptScore W2018367487C2779464278 @default.
• W2018367487 hasConceptScore W2018367487C3017461755 @default.
• W2018367487 hasConceptScore W2018367487C500558357 @default.
• W2018367487 hasConceptScore W2018367487C503630168 @default.
• W2018367487 hasConceptScore W2018367487C541997718 @default.
• W2018367487 hasConceptScore W2018367487C71924100 @default.
• W2018367487 hasIssue "5" @default.
• W2018367487 hasLocation W20183674871 @default.
• W2018367487 hasLocation W20183674872 @default.
• W2018367487 hasOpenAccess W2018367487 @default.
• W2018367487 hasPrimaryLocation W20183674871 @default.
• W2018367487 hasRelatedWork W1984767512 @default.
• W2018367487 hasRelatedWork W2028222475 @default.
• W2018367487 hasRelatedWork W2045480012 @default.
• W2018367487 hasRelatedWork W2049397185 @default.
• W2018367487 hasRelatedWork W2056943582 @default.
• W2018367487 hasRelatedWork W2067504766 @default.
• W2018367487 hasRelatedWork W2109959118 @default.
• W2018367487 hasRelatedWork W2399063111 @default.
• W2018367487 hasRelatedWork W2417879797 @default.
• W2018367487 hasRelatedWork W2794495824 @default.
• W2018367487 hasVolume "15" @default.
• W2018367487 isParatext "false" @default.
• W2018367487 isRetracted "false" @default.
• W2018367487 magId "2018367487" @default.
• W2018367487 workType "article" @default.