Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018377062> ?p ?o ?g. }
- W2018377062 endingPage "178" @default.
- W2018377062 startingPage "171" @default.
- W2018377062 abstract "The enhanced catalytic activity of lipases is often associated with structural changes. The three-dimensional (3D) structures showed that the covalently inhibited lipases exist under their open conformations, in contrast to their native closed forms. We studied the inhibition of various lipases--human and dog gastric lipases, human pancreatic lipase, and Humicola lanuginosa lipase--by the octyl-undecyl phosphonate inhibitor, and we measured the subsequent modifications of their respective electrophoretic mobility. Furthermore, the experimental values of the isoelectric points found for the native (closed) and inhibited (open) lipases are in agreement with theoretical calculations based on the electrostatic potential. We concluded that there is a significant difference in the isoelectric points between the closed (native) and open (inhibited) conformations of the four lipases investigated. Thus, analysis of the electrophoretic pattern is proposed as an easy experimental tool to differentiate between a closed and an open form of a given lipase." @default.
- W2018377062 created "2016-06-24" @default.
- W2018377062 creator A5001895147 @default.
- W2018377062 creator A5002025916 @default.
- W2018377062 creator A5004706506 @default.
- W2018377062 creator A5019852283 @default.
- W2018377062 creator A5028275110 @default.
- W2018377062 creator A5081487910 @default.
- W2018377062 date "2005-03-01" @default.
- W2018377062 modified "2023-10-17" @default.
- W2018377062 title "Discrimination between closed and open forms of lipases using electrophoretic techniques" @default.
- W2018377062 cites W138223345 @default.
- W2018377062 cites W1544211725 @default.
- W2018377062 cites W1677547851 @default.
- W2018377062 cites W1822066837 @default.
- W2018377062 cites W1933918084 @default.
- W2018377062 cites W1969172212 @default.
- W2018377062 cites W1969224656 @default.
- W2018377062 cites W1973678224 @default.
- W2018377062 cites W1975138491 @default.
- W2018377062 cites W1977323595 @default.
- W2018377062 cites W1978742480 @default.
- W2018377062 cites W1984128566 @default.
- W2018377062 cites W1984240222 @default.
- W2018377062 cites W1985011835 @default.
- W2018377062 cites W1987043378 @default.
- W2018377062 cites W1999688246 @default.
- W2018377062 cites W2004498834 @default.
- W2018377062 cites W2005863978 @default.
- W2018377062 cites W2009570597 @default.
- W2018377062 cites W2012176370 @default.
- W2018377062 cites W2015784447 @default.
- W2018377062 cites W2016012549 @default.
- W2018377062 cites W2017025152 @default.
- W2018377062 cites W2019641341 @default.
- W2018377062 cites W2020088601 @default.
- W2018377062 cites W2036414218 @default.
- W2018377062 cites W2037612112 @default.
- W2018377062 cites W2039976544 @default.
- W2018377062 cites W2040711961 @default.
- W2018377062 cites W2046429206 @default.
- W2018377062 cites W2047456928 @default.
- W2018377062 cites W2049506201 @default.
- W2018377062 cites W2049989276 @default.
- W2018377062 cites W2050335943 @default.
- W2018377062 cites W2064053352 @default.
- W2018377062 cites W2065008901 @default.
- W2018377062 cites W2067431380 @default.
- W2018377062 cites W2068686352 @default.
- W2018377062 cites W2068971591 @default.
- W2018377062 cites W2080976340 @default.
- W2018377062 cites W2082015820 @default.
- W2018377062 cites W2082584960 @default.
- W2018377062 cites W2094152940 @default.
- W2018377062 cites W2109917720 @default.
- W2018377062 cites W2111301002 @default.
- W2018377062 cites W2118383750 @default.
- W2018377062 cites W2120549005 @default.
- W2018377062 cites W2143290892 @default.
- W2018377062 cites W2324387122 @default.
- W2018377062 cites W2329478063 @default.
- W2018377062 cites W4211242772 @default.
- W2018377062 cites W4240620708 @default.
- W2018377062 doi "https://doi.org/10.1016/j.ab.2004.11.046" @default.
- W2018377062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15745736" @default.
- W2018377062 hasPublicationYear "2005" @default.
- W2018377062 type Work @default.
- W2018377062 sameAs 2018377062 @default.
- W2018377062 citedByCount "12" @default.
- W2018377062 countsByYear W20183770622012 @default.
- W2018377062 countsByYear W20183770622016 @default.
- W2018377062 countsByYear W20183770622023 @default.
- W2018377062 crossrefType "journal-article" @default.
- W2018377062 hasAuthorship W2018377062A5001895147 @default.
- W2018377062 hasAuthorship W2018377062A5002025916 @default.
- W2018377062 hasAuthorship W2018377062A5004706506 @default.
- W2018377062 hasAuthorship W2018377062A5019852283 @default.
- W2018377062 hasAuthorship W2018377062A5028275110 @default.
- W2018377062 hasAuthorship W2018377062A5081487910 @default.
- W2018377062 hasConcept C175106660 @default.
- W2018377062 hasConcept C178790620 @default.
- W2018377062 hasConcept C180577832 @default.
- W2018377062 hasConcept C181199279 @default.
- W2018377062 hasConcept C185592680 @default.
- W2018377062 hasConcept C2777626080 @default.
- W2018377062 hasConcept C2779697368 @default.
- W2018377062 hasConcept C40250595 @default.
- W2018377062 hasConcept C43617362 @default.
- W2018377062 hasConcept C50476208 @default.
- W2018377062 hasConcept C55493867 @default.
- W2018377062 hasConcept C96294017 @default.
- W2018377062 hasConceptScore W2018377062C175106660 @default.
- W2018377062 hasConceptScore W2018377062C178790620 @default.
- W2018377062 hasConceptScore W2018377062C180577832 @default.
- W2018377062 hasConceptScore W2018377062C181199279 @default.
- W2018377062 hasConceptScore W2018377062C185592680 @default.
- W2018377062 hasConceptScore W2018377062C2777626080 @default.
- W2018377062 hasConceptScore W2018377062C2779697368 @default.