FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018378575> ?p ?o ?g. }

• W2018378575 endingPage "2613" @default.
• W2018378575 startingPage "2607" @default.
• W2018378575 abstract "Our previous studies have shown that transient neonatal hypothyroidism, induced by treatment with the reversible goitrogen 6-propyl-2-thiouracil (PTU), increases testicular size and daily sperm production in the adult rat by up to 82% and 136%, respectively. The objective of the present study was to examine morphological and functional changes in adult seminiferous tubules associated with PTU-induced increases in testicular size and sperm production. Sprague-Dawley rats were treated with PTU from birth to day 25 or left untreated; for morphometry, all testes were fixed by vascular perfusion at 90 days of age. Although testicular weight was increased 62% in treated rats, gross pathological changes were not evident in these organs, and spermatogenesis appeared morphologically normal. The percent area of testis occupied by seminiferous tubules was equal in control and treated testes, but mean seminiferous tubule diameter and length were increased in the PTU-treated testis. The adult number of Sertoli cells in treated testes was increased by 157%, and the numbers of leptotene spermatocytes and round spermatids were increased 84% and 93%, respectively. These results demonstrate that increases in Sertoli cell numbers result in increased sperm production and support the idea that Sertoli cells are the major regulators of the magnitude of sperm production. Although the round spermatid to Sertoli cell ratio was reduced by nearly 30%, the number of round spermatids per g testis was increased by 14%. This increased efficiency of sperm production was accomplished by an increased density of Sertoli cells along the basement membrane and an increased height of the seminiferous epithelium. Despite the large increase in Sertoli cell numbers in treated rats, Northern blot analysis using Sertoli cell-specific cDNA probes for transferrin and androgen-binding protein indicated that relative steady state levels of mRNAs per Sertoli cell for these two secretory proteins were similar in control and treated rats at 90 days of age." @default.
• W2018378575 created "2016-06-24" @default.
• W2018378575 creator A5009194998 @default.
• W2018378575 creator A5016658159 @default.
• W2018378575 creator A5025927483 @default.
• W2018378575 creator A5038843750 @default.
• W2018378575 date "1993-06-01" @default.
• W2018378575 modified "2023-10-09" @default.
• W2018378575 title "Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers." @default.
• W2018378575 cites W1528190409 @default.
• W2018378575 cites W1600414925 @default.
• W2018378575 cites W174017481 @default.
• W2018378575 cites W1979153690 @default.
• W2018378575 cites W1991367522 @default.
• W2018378575 cites W1994728677 @default.
• W2018378575 cites W1999407487 @default.
• W2018378575 cites W2018773480 @default.
• W2018378575 cites W2027966198 @default.
• W2018378575 cites W2053969992 @default.
• W2018378575 cites W2055615962 @default.
• W2018378575 cites W2110167017 @default.
• W2018378575 cites W2119888224 @default.
• W2018378575 cites W2122693798 @default.
• W2018378575 cites W2134812217 @default.
• W2018378575 cites W2147214298 @default.
• W2018378575 cites W2157189882 @default.
• W2018378575 cites W2157857817 @default.
• W2018378575 cites W2170010825 @default.
• W2018378575 doi "https://doi.org/10.1210/endo.132.6.8504761" @default.
• W2018378575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8504761" @default.
• W2018378575 hasPublicationYear "1993" @default.
• W2018378575 type Work @default.
• W2018378575 sameAs 2018378575 @default.
• W2018378575 citedByCount "186" @default.
• W2018378575 countsByYear W20183785752012 @default.
• W2018378575 countsByYear W20183785752013 @default.
• W2018378575 countsByYear W20183785752014 @default.
• W2018378575 countsByYear W20183785752015 @default.
• W2018378575 countsByYear W20183785752016 @default.
• W2018378575 countsByYear W20183785752017 @default.
• W2018378575 countsByYear W20183785752018 @default.
• W2018378575 countsByYear W20183785752019 @default.
• W2018378575 countsByYear W20183785752020 @default.
• W2018378575 countsByYear W20183785752021 @default.
• W2018378575 countsByYear W20183785752022 @default.
• W2018378575 countsByYear W20183785752023 @default.
• W2018378575 crossrefType "journal-article" @default.
• W2018378575 hasAuthorship W2018378575A5009194998 @default.
• W2018378575 hasAuthorship W2018378575A5016658159 @default.
• W2018378575 hasAuthorship W2018378575A5025927483 @default.
• W2018378575 hasAuthorship W2018378575A5038843750 @default.
• W2018378575 hasConcept C104317684 @default.
• W2018378575 hasConcept C123765429 @default.
• W2018378575 hasConcept C126322002 @default.
• W2018378575 hasConcept C134018914 @default.
• W2018378575 hasConcept C16685009 @default.
• W2018378575 hasConcept C2777394357 @default.
• W2018378575 hasConcept C2778054371 @default.
• W2018378575 hasConcept C2779066085 @default.
• W2018378575 hasConcept C2779122487 @default.
• W2018378575 hasConcept C2781068068 @default.
• W2018378575 hasConcept C2781087480 @default.
• W2018378575 hasConcept C55493867 @default.
• W2018378575 hasConcept C71924100 @default.
• W2018378575 hasConcept C86803240 @default.
• W2018378575 hasConceptScore W2018378575C104317684 @default.
• W2018378575 hasConceptScore W2018378575C123765429 @default.
• W2018378575 hasConceptScore W2018378575C126322002 @default.
• W2018378575 hasConceptScore W2018378575C134018914 @default.
• W2018378575 hasConceptScore W2018378575C16685009 @default.
• W2018378575 hasConceptScore W2018378575C2777394357 @default.
• W2018378575 hasConceptScore W2018378575C2778054371 @default.
• W2018378575 hasConceptScore W2018378575C2779066085 @default.
• W2018378575 hasConceptScore W2018378575C2779122487 @default.
• W2018378575 hasConceptScore W2018378575C2781068068 @default.
• W2018378575 hasConceptScore W2018378575C2781087480 @default.
• W2018378575 hasConceptScore W2018378575C55493867 @default.
• W2018378575 hasConceptScore W2018378575C71924100 @default.
• W2018378575 hasConceptScore W2018378575C86803240 @default.
• W2018378575 hasIssue "6" @default.
• W2018378575 hasLocation W20183785751 @default.
• W2018378575 hasLocation W20183785752 @default.
• W2018378575 hasOpenAccess W2018378575 @default.
• W2018378575 hasPrimaryLocation W20183785751 @default.
• W2018378575 hasRelatedWork W1984253806 @default.
• W2018378575 hasRelatedWork W2020057700 @default.
• W2018378575 hasRelatedWork W2054089454 @default.
• W2018378575 hasRelatedWork W2076989556 @default.
• W2018378575 hasRelatedWork W2081055869 @default.
• W2018378575 hasRelatedWork W2097825963 @default.
• W2018378575 hasRelatedWork W2143321751 @default.
• W2018378575 hasRelatedWork W2150134508 @default.
• W2018378575 hasRelatedWork W2390728929 @default.
• W2018378575 hasRelatedWork W4214647004 @default.
• W2018378575 hasVolume "132" @default.
• W2018378575 isParatext "false" @default.
• W2018378575 isRetracted "false" @default.
• W2018378575 magId "2018378575" @default.

• next