FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018379498> ?p ?o ?g. }

• W2018379498 endingPage "255" @default.
• W2018379498 startingPage "248" @default.
• W2018379498 abstract "Biorelevant dissolution media containing bile salt and lecithin at concentrations appropriate for fed and fasted state are useful when testing oral solid formulations of poorly water-soluble drugs. Dilution of amphiphile solutions affects the aggregation state of the amphiphiles because bile salt is partitioned between the aqueous phase and the aggregates. The aim of the investigation was to study the effect of dilution on the size distribution of aggregates and its effect on the solubilization capacity. Clear buffered solutions of four intestinal amphiphiles (sodium glycocholate, lecithin, monoolein, and oleic acid) and a combination of these were prepared at high bile salt concentration. Micelles in the glycocholate solutions decreased in size when diluted. The addition of insoluble amphiphiles led to bigger micelles with no clear correlation between size of the micelles and amphiphile concentration. Dilution of the two- and four component media caused enlargement of the mixed micelles and formation of vesicles. The solubility of estradiol in the buffer solution was increased with addition of the amphiphiles. A good correlation (R2=0.987) was found between estradiol solubility and mass concentration of the amphiphiles. The results demonstrate that, in the case of estradiol, the concentration of amphiphiles rather than the aggregation state determines the solubilization capacity of the medium. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association" @default.
• W2018379498 created "2016-06-24" @default.
• W2018379498 creator A5064072022 @default.
• W2018379498 creator A5072753517 @default.
• W2018379498 creator A5091191585 @default.
• W2018379498 date "2006-02-01" @default.
• W2018379498 modified "2023-09-23" @default.
• W2018379498 title "Biorelevant dissolution media: Aggregation of amphiphiles and solubility of estradiol" @default.
• W2018379498 cites W1490573286 @default.
• W2018379498 cites W1499768710 @default.
• W2018379498 cites W1522767714 @default.
• W2018379498 cites W181458702 @default.
• W2018379498 cites W1967114224 @default.
• W2018379498 cites W1997764055 @default.
• W2018379498 cites W2012135473 @default.
• W2018379498 cites W2028021263 @default.
• W2018379498 cites W2062480286 @default.
• W2018379498 cites W2068177799 @default.
• W2018379498 cites W207649642 @default.
• W2018379498 cites W2087688721 @default.
• W2018379498 cites W2091084349 @default.
• W2018379498 cites W2095277264 @default.
• W2018379498 cites W25021539 @default.
• W2018379498 cites W52066678 @default.
• W2018379498 doi "https://doi.org/10.1002/jps.20494" @default.
• W2018379498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16374874" @default.
• W2018379498 hasPublicationYear "2006" @default.
• W2018379498 type Work @default.
• W2018379498 sameAs 2018379498 @default.
• W2018379498 citedByCount "40" @default.
• W2018379498 countsByYear W20183794982012 @default.
• W2018379498 countsByYear W20183794982014 @default.
• W2018379498 countsByYear W20183794982015 @default.
• W2018379498 countsByYear W20183794982016 @default.
• W2018379498 countsByYear W20183794982017 @default.
• W2018379498 countsByYear W20183794982018 @default.
• W2018379498 countsByYear W20183794982019 @default.
• W2018379498 countsByYear W20183794982020 @default.
• W2018379498 countsByYear W20183794982021 @default.
• W2018379498 countsByYear W20183794982022 @default.
• W2018379498 crossrefType "journal-article" @default.
• W2018379498 hasAuthorship W2018379498A5064072022 @default.
• W2018379498 hasAuthorship W2018379498A5072753517 @default.
• W2018379498 hasAuthorship W2018379498A5091191585 @default.
• W2018379498 hasConcept C11268172 @default.
• W2018379498 hasConcept C121332964 @default.
• W2018379498 hasConcept C155574463 @default.
• W2018379498 hasConcept C15920480 @default.
• W2018379498 hasConcept C178790620 @default.
• W2018379498 hasConcept C184651966 @default.
• W2018379498 hasConcept C185592680 @default.
• W2018379498 hasConcept C2776371256 @default.
• W2018379498 hasConcept C2779564620 @default.
• W2018379498 hasConcept C43617362 @default.
• W2018379498 hasConcept C4863142 @default.
• W2018379498 hasConcept C521977710 @default.
• W2018379498 hasConcept C55493867 @default.
• W2018379498 hasConcept C58226133 @default.
• W2018379498 hasConcept C67407626 @default.
• W2018379498 hasConcept C88380143 @default.
• W2018379498 hasConcept C96618451 @default.
• W2018379498 hasConcept C97355855 @default.
• W2018379498 hasConceptScore W2018379498C11268172 @default.
• W2018379498 hasConceptScore W2018379498C121332964 @default.
• W2018379498 hasConceptScore W2018379498C155574463 @default.
• W2018379498 hasConceptScore W2018379498C15920480 @default.
• W2018379498 hasConceptScore W2018379498C178790620 @default.
• W2018379498 hasConceptScore W2018379498C184651966 @default.
• W2018379498 hasConceptScore W2018379498C185592680 @default.
• W2018379498 hasConceptScore W2018379498C2776371256 @default.
• W2018379498 hasConceptScore W2018379498C2779564620 @default.
• W2018379498 hasConceptScore W2018379498C43617362 @default.
• W2018379498 hasConceptScore W2018379498C4863142 @default.
• W2018379498 hasConceptScore W2018379498C521977710 @default.
• W2018379498 hasConceptScore W2018379498C55493867 @default.
• W2018379498 hasConceptScore W2018379498C58226133 @default.
• W2018379498 hasConceptScore W2018379498C67407626 @default.
• W2018379498 hasConceptScore W2018379498C88380143 @default.
• W2018379498 hasConceptScore W2018379498C96618451 @default.
• W2018379498 hasConceptScore W2018379498C97355855 @default.
• W2018379498 hasIssue "2" @default.
• W2018379498 hasLocation W20183794981 @default.
• W2018379498 hasLocation W20183794982 @default.
• W2018379498 hasOpenAccess W2018379498 @default.
• W2018379498 hasPrimaryLocation W20183794981 @default.
• W2018379498 hasRelatedWork W1002471555 @default.
• W2018379498 hasRelatedWork W2004271396 @default.
• W2018379498 hasRelatedWork W2010589369 @default.
• W2018379498 hasRelatedWork W2018379498 @default.
• W2018379498 hasRelatedWork W2086595608 @default.
• W2018379498 hasRelatedWork W2112566419 @default.
• W2018379498 hasRelatedWork W2391982268 @default.
• W2018379498 hasRelatedWork W3024223573 @default.
• W2018379498 hasRelatedWork W2067587700 @default.
• W2018379498 hasRelatedWork W2188737815 @default.
• W2018379498 hasVolume "95" @default.
• W2018379498 isParatext "false" @default.
• W2018379498 isRetracted "false" @default.

• next