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- W2018380327 abstract "OBJECTIVES: Whilst differences between Caucasian, African and Asian menopausal women have been well documented, the aim of this study is to explore the relationship between menopause, HRT use and aspects of quality of life (QoL) across five European countries. METHODS: A large-scale observational study of women's health in France, Germany, Italy, Poland, UK was conducted with 7806 women, aged 45–65, and consulting gynecologists or primary care physicians (n = 530). QoL was assessed with the Women's Health Questionnaire (vasomotor, depressed mood and sexual behavior scales). RESULTS: Mean age (range 52.5 to 54.7) and time since menopause were similar across all countries. Findings suggested differential use of HRT across Europe (current or lapsed): high in Germany (68%), low in France (50%) and Italy (49%) (chi-square = 139, P < 0.001). We compared aspects of QoL between users and non-users (stratified by time since menopause). Within 5 years of menopause HRT users experienced: significantly fewer vasomotor symptoms than non-HRT users across all countries (z = −15,9 p < 0.001); significantly less depression (z = −10.5, P < 0.001) across all countries except the UK, and significantly better sexual functioning in Italy and Germany (z = −7.6, p < 0.001). For women experiencing menopause over 5 years ago, HRT users had better scores in sexual (z = −12.2, P < 0.001) and mood (z = −3.0, P 0.002) domains than non-users in all countries, but no differences were observed for vasomotor symptoms. CONCLUSIONS: Within 5 years of menopause, HRT improves those aspects of menopausal symptoms which are most important to women at that time in their lives (vasomotor symptoms, mood) irrespective of country. After 5 years, across countries, the impact of vasomotor symptoms on women naturally decreases and thus HRT users no longer experience a benefit over non-users. However, the benefits of HRT on sexual functioning and mood continue. These findings suggest that pooling European WHQ data may be appropriate." @default.
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- W2018380327 date "2001-09-01" @default.
- W2018380327 modified "2023-09-29" @default.
- W2018380327 title "PWM8: QUALITY OF LIFE IN POST-MENOPAUSAL WOMEN IN FIVE EUROPEAN COUNTRIES" @default.
- W2018380327 doi "https://doi.org/10.1046/j.1524-4733.2001.40202-260.x" @default.
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