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• W2018381844 endingPage "457" @default.
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• W2018381844 abstract "The therapeutic management of parapneumonic pleural effusions (PPE) is controversial in children. Decision-making often relies on parameters such as gross appearance of pleural fluid and on bacteriologic and biochemical analyses. Our goal was to describe the laboratory profile of PPE in children and to assess the influence of previous administration of antibacterial agents on culture and biochemical results.This was a prospective study including children (age, 1 month to 16 years) with a diagnosis of PPE. Two groups were evaluated: children with or without antibiotic treatment up to 48 hours before analysis of pleural fluid. Results were analyzed using the χ(2) or Mann-Whitney test (α = .05). Odds ratio and 95% confidence intervals (95% CIs) were calculated, with control of previous antibiotic therapy using multivariate logistic regression analysis, to determine the risk of empyema associated with specific biochemical parameters.One hundred ten children were selected. Fifty percent had received antibiotics at least 48 hours before pleural fluid analysis. Differences were observed between the groups in terms of PPE gross appearance (P = .033) and identification of bacteriologic agent by culture or Gram stain (P = .023). Biochemical parameters (pH ≤7.1 and glucose ≤40 mg/dL) were associated with increased odds of receiving a more invasive treatment. For pH, the odds ratio was 9.614 (95% CI, 1.952-47.362; P = .005); and for glucose, 9.201 (95% CI, 1.333-63.496; P = .024).Previous use of antibacterial agents affected the bacteriologic analysis of pleural fluid in this pediatric sample admitted for PPE. However, it did not interfere significantly with biochemical parameters of pleural fluid." @default.
• W2018381844 created "2016-06-24" @default.
• W2018381844 creator A5005757601 @default.
• W2018381844 creator A5017357382 @default.
• W2018381844 creator A5031334378 @default.
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• W2018381844 date "2011-03-01" @default.
• W2018381844 modified "2023-09-23" @default.
• W2018381844 title "Impact of antibiotic therapy on laboratory analysis of parapneumonic pleural fluid in children" @default.
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• W2018381844 doi "https://doi.org/10.1016/j.jpedsurg.2010.09.003" @default.
• W2018381844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21376191" @default.
• W2018381844 hasPublicationYear "2011" @default.
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