Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018386312> ?p ?o ?g. }
- W2018386312 endingPage "156" @default.
- W2018386312 startingPage "149" @default.
- W2018386312 abstract "Gamma 3-melanotropin (gamma 3-MSH) facilitates a rapid, dose-dependent, and cycloheximide-insensitive increase in the concentration of mitochondrial free cholesterol in the adrenals of hypophysectomized rats. Physiological concentrations of various synthetic and native preparations of gamma 3-MSH are potent, while gamma-MSH is not. This cholesterol accumulation coincides with the activation of cholesteryl ester hydrolysis by gamma 3-MSH, while the rates of cholesterol esterification and of mitochondrial cholesterol side-chain cleavage are unaffected. Conversely, ACTH inhibits cholesterol ester esterification. Therefore, gamma 3-MSH and ACTH together may coordinate a substantial shift in the set-point of cholesteryl ester in equilibrium cholesterol cycling toward the right. Because ACTH also activates cholesterol side-chain cleavage, this coordinate effect on the flux of cholesterol substrate is manifest as a potentiation of corticosteroidogenesis by gamma 3-MSH. These data extend our previous studies demonstrating that pro-gamma-MSH polypeptides have an endocrine influence on the rat adrenal cortex." @default.
- W2018386312 created "2016-06-24" @default.
- W2018386312 creator A5021733466 @default.
- W2018386312 creator A5025462873 @default.
- W2018386312 date "1987-03-01" @default.
- W2018386312 modified "2023-09-27" @default.
- W2018386312 title "Gamma3-melanotropin promotes mitochondrial cholesterol accumulation in the rat adrenal cortex" @default.
- W2018386312 cites W13155899 @default.
- W2018386312 cites W1507633654 @default.
- W2018386312 cites W1516751460 @default.
- W2018386312 cites W1518166130 @default.
- W2018386312 cites W1534553674 @default.
- W2018386312 cites W1552809292 @default.
- W2018386312 cites W1578839852 @default.
- W2018386312 cites W1586039665 @default.
- W2018386312 cites W1631661863 @default.
- W2018386312 cites W1699722065 @default.
- W2018386312 cites W179357761 @default.
- W2018386312 cites W1940775645 @default.
- W2018386312 cites W1951469402 @default.
- W2018386312 cites W1973496718 @default.
- W2018386312 cites W1975651762 @default.
- W2018386312 cites W1976749670 @default.
- W2018386312 cites W1978420247 @default.
- W2018386312 cites W1983778724 @default.
- W2018386312 cites W1986985855 @default.
- W2018386312 cites W1991747975 @default.
- W2018386312 cites W1992902250 @default.
- W2018386312 cites W2002023611 @default.
- W2018386312 cites W2003502707 @default.
- W2018386312 cites W2005049643 @default.
- W2018386312 cites W2015433191 @default.
- W2018386312 cites W2017402132 @default.
- W2018386312 cites W2023822557 @default.
- W2018386312 cites W2027032504 @default.
- W2018386312 cites W2027206003 @default.
- W2018386312 cites W2034988832 @default.
- W2018386312 cites W2037785646 @default.
- W2018386312 cites W2040634683 @default.
- W2018386312 cites W2040989387 @default.
- W2018386312 cites W2043017646 @default.
- W2018386312 cites W2043317611 @default.
- W2018386312 cites W2043956348 @default.
- W2018386312 cites W2053245866 @default.
- W2018386312 cites W2067492361 @default.
- W2018386312 cites W2068996099 @default.
- W2018386312 cites W2073411639 @default.
- W2018386312 cites W2073715060 @default.
- W2018386312 cites W2078203191 @default.
- W2018386312 cites W2081687544 @default.
- W2018386312 cites W2083702892 @default.
- W2018386312 cites W2087328208 @default.
- W2018386312 cites W2087343995 @default.
- W2018386312 cites W2089018293 @default.
- W2018386312 cites W2117380023 @default.
- W2018386312 cites W2131736525 @default.
- W2018386312 cites W2152311269 @default.
- W2018386312 cites W2164659074 @default.
- W2018386312 cites W2165482355 @default.
- W2018386312 cites W2165932004 @default.
- W2018386312 cites W26854014 @default.
- W2018386312 cites W4293247451 @default.
- W2018386312 cites W74869526 @default.
- W2018386312 doi "https://doi.org/10.1016/0303-7207(87)90087-6" @default.
- W2018386312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3582725" @default.
- W2018386312 hasPublicationYear "1987" @default.
- W2018386312 type Work @default.
- W2018386312 sameAs 2018386312 @default.
- W2018386312 citedByCount "15" @default.
- W2018386312 countsByYear W20183863122014 @default.
- W2018386312 crossrefType "journal-article" @default.
- W2018386312 hasAuthorship W2018386312A5021733466 @default.
- W2018386312 hasAuthorship W2018386312A5025462873 @default.
- W2018386312 hasConcept C126322002 @default.
- W2018386312 hasConcept C134018914 @default.
- W2018386312 hasConcept C151730666 @default.
- W2018386312 hasConcept C175156509 @default.
- W2018386312 hasConcept C185592680 @default.
- W2018386312 hasConcept C2776448209 @default.
- W2018386312 hasConcept C2777977426 @default.
- W2018386312 hasConcept C2778128677 @default.
- W2018386312 hasConcept C2778163477 @default.
- W2018386312 hasConcept C2780072125 @default.
- W2018386312 hasConcept C3675279 @default.
- W2018386312 hasConcept C43369102 @default.
- W2018386312 hasConcept C526171541 @default.
- W2018386312 hasConcept C55493867 @default.
- W2018386312 hasConcept C62231903 @default.
- W2018386312 hasConcept C71924100 @default.
- W2018386312 hasConcept C80446465 @default.
- W2018386312 hasConcept C86803240 @default.
- W2018386312 hasConceptScore W2018386312C126322002 @default.
- W2018386312 hasConceptScore W2018386312C134018914 @default.
- W2018386312 hasConceptScore W2018386312C151730666 @default.
- W2018386312 hasConceptScore W2018386312C175156509 @default.
- W2018386312 hasConceptScore W2018386312C185592680 @default.
- W2018386312 hasConceptScore W2018386312C2776448209 @default.
- W2018386312 hasConceptScore W2018386312C2777977426 @default.