FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018386315> ?p ?o ?g. }

• W2018386315 endingPage "468" @default.
• W2018386315 startingPage "463" @default.
• W2018386315 abstract "Physiological regulation of Ca(2+) release from the endoplasmic reticulum (ER) is critical for cell function. Recent direct measurements of free [Ca(2+)] inside the ER ([Ca(2+)](ER)) revealed that [Ca(2+)](ER) itself is a key regulator of ER Ca(2+) handling. However, the role of this new regulatory process in generating various patterns of Ca(2+) release remains to be elucidated in detail. Here, we incorporate the recently quantified experimental correlations between [Ca(2+)](ER) and Ca(2+) movements across the ER membrane into a mathematical model ER Ca(2+) handling. The model reproduces basic experimental dynamics of [Ca(2+)](ER). Although this was not goal in model design, the model also exhibits mechanistically unclear experimental phenomena such as quantal Ca(2+) release, and store charging by increasing resting cytosolic [Ca(2+)]. While more complex explanations cannot be ruled out, on the basis of our data we propose that quantal release and store charging could be simple re-equilibration phenomena, predicted by the recently quantified biophysical dynamics of Ca(2+) movements across the ER membrane." @default.
• W2018386315 created "2016-06-24" @default.
• W2018386315 creator A5031535677 @default.
• W2018386315 creator A5083227570 @default.
• W2018386315 date "2005-12-22" @default.
• W2018386315 modified "2023-10-17" @default.
• W2018386315 title "Biophysical re-equilibration of Ca²⁺fluxes as a simple biologically plausible explanation for complex intracellular Ca²⁺release patterns" @default.
• W2018386315 cites W1485297825 @default.
• W2018386315 cites W1490897378 @default.
• W2018386315 cites W1535365166 @default.
• W2018386315 cites W1555351713 @default.
• W2018386315 cites W1572568267 @default.
• W2018386315 cites W1598957092 @default.
• W2018386315 cites W1604195904 @default.
• W2018386315 cites W1673140014 @default.
• W2018386315 cites W1918906452 @default.
• W2018386315 cites W1943804967 @default.
• W2018386315 cites W1965050631 @default.
• W2018386315 cites W1970399273 @default.
• W2018386315 cites W1977150932 @default.
• W2018386315 cites W1980997572 @default.
• W2018386315 cites W1985940938 @default.
• W2018386315 cites W1986311952 @default.
• W2018386315 cites W1992045485 @default.
• W2018386315 cites W1997018082 @default.
• W2018386315 cites W2005170876 @default.
• W2018386315 cites W2005668432 @default.
• W2018386315 cites W2009225669 @default.
• W2018386315 cites W2010756788 @default.
• W2018386315 cites W2016770416 @default.
• W2018386315 cites W2019136932 @default.
• W2018386315 cites W2034507898 @default.
• W2018386315 cites W2050240114 @default.
• W2018386315 cites W2057953411 @default.
• W2018386315 cites W2076199082 @default.
• W2018386315 cites W2080827573 @default.
• W2018386315 cites W2081847677 @default.
• W2018386315 cites W2087681173 @default.
• W2018386315 cites W2094936060 @default.
• W2018386315 cites W2103013784 @default.
• W2018386315 cites W2106959472 @default.
• W2018386315 cites W2110841019 @default.
• W2018386315 cites W2122054000 @default.
• W2018386315 cites W2123967696 @default.
• W2018386315 cites W2129386380 @default.
• W2018386315 cites W2132047598 @default.
• W2018386315 cites W2138377715 @default.
• W2018386315 cites W2144190351 @default.
• W2018386315 cites W2169854908 @default.
• W2018386315 cites W2171359667 @default.
• W2018386315 cites W4249424055 @default.
• W2018386315 doi "https://doi.org/10.1016/j.febslet.2005.12.042" @default.
• W2018386315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16386246" @default.
• W2018386315 hasPublicationYear "2005" @default.
• W2018386315 type Work @default.
• W2018386315 sameAs 2018386315 @default.
• W2018386315 citedByCount "19" @default.
• W2018386315 countsByYear W20183863152013 @default.
• W2018386315 countsByYear W20183863152014 @default.
• W2018386315 countsByYear W20183863152020 @default.
• W2018386315 countsByYear W20183863152021 @default.
• W2018386315 crossrefType "journal-article" @default.
• W2018386315 hasAuthorship W2018386315A5031535677 @default.
• W2018386315 hasAuthorship W2018386315A5083227570 @default.
• W2018386315 hasConcept C12554922 @default.
• W2018386315 hasConcept C158617107 @default.
• W2018386315 hasConcept C181199279 @default.
• W2018386315 hasConcept C185592680 @default.
• W2018386315 hasConcept C55493867 @default.
• W2018386315 hasConcept C79879829 @default.
• W2018386315 hasConcept C86803240 @default.
• W2018386315 hasConcept C98539663 @default.
• W2018386315 hasConceptScore W2018386315C12554922 @default.
• W2018386315 hasConceptScore W2018386315C158617107 @default.
• W2018386315 hasConceptScore W2018386315C181199279 @default.
• W2018386315 hasConceptScore W2018386315C185592680 @default.
• W2018386315 hasConceptScore W2018386315C55493867 @default.
• W2018386315 hasConceptScore W2018386315C79879829 @default.
• W2018386315 hasConceptScore W2018386315C86803240 @default.
• W2018386315 hasConceptScore W2018386315C98539663 @default.
• W2018386315 hasIssue "2" @default.
• W2018386315 hasLocation W20183863151 @default.
• W2018386315 hasLocation W20183863152 @default.
• W2018386315 hasOpenAccess W2018386315 @default.
• W2018386315 hasPrimaryLocation W20183863151 @default.
• W2018386315 hasRelatedWork W1531601525 @default.
• W2018386315 hasRelatedWork W1548027523 @default.
• W2018386315 hasRelatedWork W2072105226 @default.
• W2018386315 hasRelatedWork W2132261509 @default.
• W2018386315 hasRelatedWork W2607424097 @default.
• W2018386315 hasRelatedWork W2748952813 @default.
• W2018386315 hasRelatedWork W2899084033 @default.
• W2018386315 hasRelatedWork W2948807893 @default.
• W2018386315 hasRelatedWork W4387497383 @default.
• W2018386315 hasRelatedWork W2778153218 @default.
• W2018386315 hasVolume "580" @default.
• W2018386315 isParatext "false" @default.
• W2018386315 isRetracted "false" @default.

• next