FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018386436> ?p ?o ?g. }

• W2018386436 endingPage "8360" @default.
• W2018386436 startingPage "8356" @default.
• W2018386436 abstract "V(D)J recombination occurs during the antigen-independent early steps of B-cell ontogeny. Multiple IgH cis-regulatory elements control B-cell ontogeny. IGCR1 (intergenic control region 1), the DQ52 promoter/enhancer, and the intronic Emu enhancer, all three located upstream of Cmu, have important roles during V(D)J recombination, whereas there is no clue about a role of the IgH regulatory region (RR) encompassing the four transcriptional enhancers hs3a, hs1,2, hs3b, and hs4 during these early stages. To clarify the role of the RR in V(D)J recombination, we totally deleted it in the mouse genome. Here, we show that V(D)J recombination is unaffected by the complete absence of the IgH RR, highlighting that this region only orchestrates IgH locus activity during the late stages of B-cell differentiation. In contrast, the earliest antigen-independent steps of B-cell ontogeny would be under the control of only the upstream Cmu elements of the locus. V(D)J recombination occurs during the antigen-independent early steps of B-cell ontogeny. Multiple IgH cis-regulatory elements control B-cell ontogeny. IGCR1 (intergenic control region 1), the DQ52 promoter/enhancer, and the intronic Emu enhancer, all three located upstream of Cmu, have important roles during V(D)J recombination, whereas there is no clue about a role of the IgH regulatory region (RR) encompassing the four transcriptional enhancers hs3a, hs1,2, hs3b, and hs4 during these early stages. To clarify the role of the RR in V(D)J recombination, we totally deleted it in the mouse genome. Here, we show that V(D)J recombination is unaffected by the complete absence of the IgH RR, highlighting that this region only orchestrates IgH locus activity during the late stages of B-cell differentiation. In contrast, the earliest antigen-independent steps of B-cell ontogeny would be under the control of only the upstream Cmu elements of the locus." @default.
• W2018386436 created "2016-06-24" @default.
• W2018386436 creator A5035902340 @default.
• W2018386436 creator A5048010568 @default.
• W2018386436 creator A5051446250 @default.
• W2018386436 creator A5061875124 @default.
• W2018386436 creator A5063574799 @default.
• W2018386436 creator A5066694566 @default.
• W2018386436 date "2012-03-01" @default.
• W2018386436 modified "2023-10-15" @default.
• W2018386436 title "Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination" @default.
• W2018386436 cites W1730627473 @default.
• W2018386436 cites W1813376539 @default.
• W2018386436 cites W182737502 @default.
• W2018386436 cites W1901046328 @default.
• W2018386436 cites W1967867591 @default.
• W2018386436 cites W1980546626 @default.
• W2018386436 cites W1995291122 @default.
• W2018386436 cites W2001802639 @default.
• W2018386436 cites W2021193053 @default.
• W2018386436 cites W2022262778 @default.
• W2018386436 cites W2026664902 @default.
• W2018386436 cites W2036859226 @default.
• W2018386436 cites W2052962666 @default.
• W2018386436 cites W2063190879 @default.
• W2018386436 cites W2079858112 @default.
• W2018386436 cites W2098660045 @default.
• W2018386436 cites W2109948886 @default.
• W2018386436 cites W2114930786 @default.
• W2018386436 cites W2117455815 @default.
• W2018386436 cites W2126450670 @default.
• W2018386436 cites W2129883110 @default.
• W2018386436 cites W2155487178 @default.
• W2018386436 doi "https://doi.org/10.1074/jbc.m112.341024" @default.
• W2018386436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3318744" @default.
• W2018386436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22270371" @default.
• W2018386436 hasPublicationYear "2012" @default.
• W2018386436 type Work @default.
• W2018386436 sameAs 2018386436 @default.
• W2018386436 citedByCount "34" @default.
• W2018386436 countsByYear W20183864362012 @default.
• W2018386436 countsByYear W20183864362013 @default.
• W2018386436 countsByYear W20183864362014 @default.
• W2018386436 countsByYear W20183864362015 @default.
• W2018386436 countsByYear W20183864362016 @default.
• W2018386436 countsByYear W20183864362017 @default.
• W2018386436 countsByYear W20183864362018 @default.
• W2018386436 countsByYear W20183864362019 @default.
• W2018386436 countsByYear W20183864362020 @default.
• W2018386436 countsByYear W20183864362021 @default.
• W2018386436 countsByYear W20183864362022 @default.
• W2018386436 crossrefType "journal-article" @default.
• W2018386436 hasAuthorship W2018386436A5035902340 @default.
• W2018386436 hasAuthorship W2018386436A5048010568 @default.
• W2018386436 hasAuthorship W2018386436A5051446250 @default.
• W2018386436 hasAuthorship W2018386436A5061875124 @default.
• W2018386436 hasAuthorship W2018386436A5063574799 @default.
• W2018386436 hasAuthorship W2018386436A5066694566 @default.
• W2018386436 hasBestOaLocation W20183864361 @default.
• W2018386436 hasConcept C104317684 @default.
• W2018386436 hasConcept C111936080 @default.
• W2018386436 hasConcept C153911025 @default.
• W2018386436 hasConcept C156695909 @default.
• W2018386436 hasConcept C165864922 @default.
• W2018386436 hasConcept C21592294 @default.
• W2018386436 hasConcept C2780254951 @default.
• W2018386436 hasConcept C54355233 @default.
• W2018386436 hasConcept C84597430 @default.
• W2018386436 hasConcept C86339819 @default.
• W2018386436 hasConcept C86803240 @default.
• W2018386436 hasConceptScore W2018386436C104317684 @default.
• W2018386436 hasConceptScore W2018386436C111936080 @default.
• W2018386436 hasConceptScore W2018386436C153911025 @default.
• W2018386436 hasConceptScore W2018386436C156695909 @default.
• W2018386436 hasConceptScore W2018386436C165864922 @default.
• W2018386436 hasConceptScore W2018386436C21592294 @default.
• W2018386436 hasConceptScore W2018386436C2780254951 @default.
• W2018386436 hasConceptScore W2018386436C54355233 @default.
• W2018386436 hasConceptScore W2018386436C84597430 @default.
• W2018386436 hasConceptScore W2018386436C86339819 @default.
• W2018386436 hasConceptScore W2018386436C86803240 @default.
• W2018386436 hasIssue "11" @default.
• W2018386436 hasLocation W20183864361 @default.
• W2018386436 hasLocation W20183864362 @default.
• W2018386436 hasLocation W20183864363 @default.
• W2018386436 hasLocation W20183864364 @default.
• W2018386436 hasLocation W20183864365 @default.
• W2018386436 hasLocation W20183864366 @default.
• W2018386436 hasOpenAccess W2018386436 @default.
• W2018386436 hasPrimaryLocation W20183864361 @default.
• W2018386436 hasRelatedWork W1986909515 @default.
• W2018386436 hasRelatedWork W1998473849 @default.
• W2018386436 hasRelatedWork W2028706937 @default.
• W2018386436 hasRelatedWork W2050359948 @default.
• W2018386436 hasRelatedWork W2070964166 @default.
• W2018386436 hasRelatedWork W2072149435 @default.
• W2018386436 hasRelatedWork W2106188260 @default.
• W2018386436 hasRelatedWork W2167063030 @default.

• next