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- W2018388545 abstract "Progressive multifocal leukoencephalopathy developed in a 21-year-old woman 2 years after renal transplantation using a cadaver as donor. Good renal function was observed with the exception of two reversible episodes of rejection during the first 6 months. Neurological signs began in the right arm. Their progressive extension resulted in death after 5 months. Brain scans and arteriograms were repeatedly normal. Cerebral atrophy was shown by air encephalography. Post-mortem examination showed many areas of necrosis and demyelination in both cerebral hemispheres and in the cerebellum. Electron microscopy showed spherical and filamentous virion particles in nuclei of glial cells and macrophages, highly suggestive of papova virus infection. Immunosuppression should be considered as the main factor leading to the increased risk of such complications in transplant cases. New diagnostic procedures, perhaps including brain biopsy should lead to early diagnosis which would justify stopping immunosuppressive drugs, perhaps allowing spontaneous eradication of the viral infection. Such an approach could induce destruction of the graft requiring that the patient be re-established on a chronic hemodialysis programme." @default.
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- W2018388545 date "1974-09-01" @default.
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- W2018388545 title "Leuco-encéphalopathie multifocale progressive après transplantation rénale" @default.
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- W2018388545 doi "https://doi.org/10.1016/0022-510x(74)90141-5" @default.
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