Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018389969> ?p ?o ?g. }
- W2018389969 endingPage "726" @default.
- W2018389969 startingPage "715" @default.
- W2018389969 abstract "Although studies of epileptic human hippocampus suggest changes of synaptic and intrinsic excitability, few changes, save the appearance of spontaneous field/synaptic potentials, are known in epileptic neocortical tissue. However, invasive EEG and histological studies suggest that neocortical tissue, even in mesial temporal lobe epilepsy, can play an important role as an irritative zone or extrahippocampal focus. We hypothesized that intrinsic neuronal and synaptic excitability, as well as short-term plasticity, are altered in neocortical areas, particularly with elevated K+ levels as occur during seizures. We analyzed neuronal firing properties, synaptic responses, and paired-pulse plasticity in human neocortical slices from tissue resected during epilepsy surgery, both under normal and under pathological conditions, i.e., after elevating K+ (4/8 mM), with rat neocortical slices as controls. Neuronal firing properties were not different. We did find, however, alterations of synaptic responsiveness in epileptic tissue, i.e., an elevated network excitability with K+ elevations, and reduction of paired-pulse depression. © 2005 Wiley-Liss, Inc." @default.
- W2018389969 created "2016-06-24" @default.
- W2018389969 creator A5017714383 @default.
- W2018389969 creator A5019105584 @default.
- W2018389969 creator A5027207476 @default.
- W2018389969 creator A5048082682 @default.
- W2018389969 creator A5048879712 @default.
- W2018389969 creator A5083883065 @default.
- W2018389969 creator A5086778430 @default.
- W2018389969 date "2005-06-01" @default.
- W2018389969 modified "2023-10-16" @default.
- W2018389969 title "Intrinsic excitability, synaptic potentials, and short-term plasticity in human epileptic neocortex" @default.
- W2018389969 cites W131216487 @default.
- W2018389969 cites W1540301663 @default.
- W2018389969 cites W1643173510 @default.
- W2018389969 cites W1749817144 @default.
- W2018389969 cites W1753065719 @default.
- W2018389969 cites W1774260123 @default.
- W2018389969 cites W1859373736 @default.
- W2018389969 cites W1956234306 @default.
- W2018389969 cites W1966621020 @default.
- W2018389969 cites W1967512267 @default.
- W2018389969 cites W1971977652 @default.
- W2018389969 cites W1976291966 @default.
- W2018389969 cites W1979440162 @default.
- W2018389969 cites W1980441615 @default.
- W2018389969 cites W1982621945 @default.
- W2018389969 cites W1985692923 @default.
- W2018389969 cites W1994568892 @default.
- W2018389969 cites W1995646392 @default.
- W2018389969 cites W2000567031 @default.
- W2018389969 cites W2000850478 @default.
- W2018389969 cites W2001283723 @default.
- W2018389969 cites W2004115145 @default.
- W2018389969 cites W2010923255 @default.
- W2018389969 cites W2011035047 @default.
- W2018389969 cites W2021401120 @default.
- W2018389969 cites W2029351017 @default.
- W2018389969 cites W2040873165 @default.
- W2018389969 cites W2041046463 @default.
- W2018389969 cites W2042256286 @default.
- W2018389969 cites W2050250937 @default.
- W2018389969 cites W2066456183 @default.
- W2018389969 cites W2069586118 @default.
- W2018389969 cites W2071529758 @default.
- W2018389969 cites W2072036379 @default.
- W2018389969 cites W2074261334 @default.
- W2018389969 cites W2080778713 @default.
- W2018389969 cites W2094618156 @default.
- W2018389969 cites W2103934527 @default.
- W2018389969 cites W2120492231 @default.
- W2018389969 cites W2127019545 @default.
- W2018389969 cites W2132971540 @default.
- W2018389969 cites W2143625506 @default.
- W2018389969 cites W2143998666 @default.
- W2018389969 cites W2152133933 @default.
- W2018389969 cites W2154508911 @default.
- W2018389969 cites W2157544393 @default.
- W2018389969 cites W2158584405 @default.
- W2018389969 cites W2169599134 @default.
- W2018389969 cites W2291381512 @default.
- W2018389969 cites W2295404329 @default.
- W2018389969 cites W2303631713 @default.
- W2018389969 cites W2345228660 @default.
- W2018389969 cites W2397982414 @default.
- W2018389969 cites W2398614193 @default.
- W2018389969 cites W2406996506 @default.
- W2018389969 cites W2460463858 @default.
- W2018389969 doi "https://doi.org/10.1002/jnr.20498" @default.
- W2018389969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15880382" @default.
- W2018389969 hasPublicationYear "2005" @default.
- W2018389969 type Work @default.
- W2018389969 sameAs 2018389969 @default.
- W2018389969 citedByCount "30" @default.
- W2018389969 countsByYear W20183899692012 @default.
- W2018389969 countsByYear W20183899692013 @default.
- W2018389969 countsByYear W20183899692014 @default.
- W2018389969 countsByYear W20183899692015 @default.
- W2018389969 countsByYear W20183899692016 @default.
- W2018389969 countsByYear W20183899692017 @default.
- W2018389969 countsByYear W20183899692019 @default.
- W2018389969 countsByYear W20183899692020 @default.
- W2018389969 countsByYear W20183899692022 @default.
- W2018389969 crossrefType "journal-article" @default.
- W2018389969 hasAuthorship W2018389969A5017714383 @default.
- W2018389969 hasAuthorship W2018389969A5019105584 @default.
- W2018389969 hasAuthorship W2018389969A5027207476 @default.
- W2018389969 hasAuthorship W2018389969A5048082682 @default.
- W2018389969 hasAuthorship W2018389969A5048879712 @default.
- W2018389969 hasAuthorship W2018389969A5083883065 @default.
- W2018389969 hasAuthorship W2018389969A5086778430 @default.
- W2018389969 hasConcept C15744967 @default.
- W2018389969 hasConcept C169760540 @default.
- W2018389969 hasConcept C170493617 @default.
- W2018389969 hasConcept C2777222312 @default.
- W2018389969 hasConcept C2778186239 @default.
- W2018389969 hasConcept C2781161787 @default.
- W2018389969 hasConcept C47611674 @default.