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- W2018398002 abstract "The virus-responsive element of the IFN-α 1 promoter, VRE(IFNα), comprises two imperfect 19 bp repeats, repA and repB. VRE(IFNα), tetrameric repA, and tetrameric GAAAGT (a subsequence of repB) or tetrameric AAGTGA conferred inducibility on a reporter gene when placed upstream of a complete or truncated promoter. Induced transcription was weak with a minimal promoter (TATA box only), but was strongly stimulated by the SV40 enhancer placed immediately upstream of the inducible element. Surprisingly, under noninduced conditions, tetrameric repA, GAAAGT, and AAGTGA (but not VRE(IFNα)) completely silenced enhancement of constitutive transcription by the SV40 72 bp repeat when interposed between the latter and the TATA box; silencing was fully abrogated by induction." @default.
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- W2018398002 date "1987-09-01" @default.
- W2018398002 modified "2023-09-23" @default.
- W2018398002 title "Reversible silencing of enhancers by sequences derived from the human IFN-α promoter" @default.
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- W2018398002 doi "https://doi.org/10.1016/0092-8674(87)90172-3" @default.
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