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- W2018399277 abstract "Serotonin (5-hydroxytryptamine; 5HT), secreted from the aggregating platelets, produces a multitude of different physiological effects especially on the cardiovascular systems through its specific receptors. These serotonergic receptors are divided into seven distinct classes (5HT1–5HT7) mainly on the basis of their structural and operational characteristics [ [1] Nebigil C.G Maroteaux L A novel role for serotonin in heart. Trends Cardiovasc. Med. 2001; 11: 329-335 Abstract Full Text Full Text PDF PubMed Scopus (72) Google Scholar ]. Among them, 5HT2 receptor is well characterized with respect to the functions. Activation of 5HT2 receptor on platelets induces platelet aggregation. The clinical studies by using the specific 5HT2 receptor antagonists also showed that 5HT2 receptor dysfunction was involved in the etiology of cardiovascular diseases [ [2] Vanhoutte P.M Platelet-derived serotonin, the endothelium and cardiovascular disease. J. Cardiovasc. Pharmacol. 1991; 17: S6-S12 PubMed Google Scholar ]." @default.
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- W2018399277 date "2003-01-01" @default.
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- W2018399277 title "Serotonin-2A receptor gene polymorphisms are associated with serotonin-induced platelet aggregation" @default.
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