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- W2018404220 endingPage "1483" @default.
- W2018404220 startingPage "1471" @default.
- W2018404220 abstract "The development of medications used in the treatment of epilepsy has accelerated over the past decade, and has benefited from a parallel growth in our knowledge of the basic mechanisms underlying neuronal excitability and synchronization. This understanding of the pharmacologic basis of antiepileptic drug (AED) action has, in large part, arisen from recent advances in cellular and molecular biology, coupled with avenues of drug discovery that have departed somewhat from the largely empiric approaches of the past. Physicians now have available to them an ever-growing armentarium of AEDs, necessitating a firmer appreciation of their mechanisms of action if more rational approaches toward both clinical application and research are to be adopted. An important example in this regard is the concept of rational polypharmacy for patients with epilepsy who are refractory to monotherapy. This review summarizes our current understanding of the molecular targets of clinically significant AEDs, comparing and contrasting their differing mechanisms of action." @default.
- W2018404220 created "2016-06-24" @default.
- W2018404220 creator A5010085174 @default.
- W2018404220 creator A5041773724 @default.
- W2018404220 date "1999-11-01" @default.
- W2018404220 modified "2023-10-11" @default.
- W2018404220 title "The Pharmacologic Basis of Antiepileptic Drug Action" @default.
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