FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018406848> ?p ?o ?g. }

• W2018406848 abstract "To compare the effect of orchidectomy (ODX) in 7- and 24-week-old C57BL/6 mice on the age-related responses of the cytokine interleukin (IL)-1beta and its receptor to intraperitoneal injection of the bacterial endotoxin, lipopolysaccharide (LPS).We measured IL-1beta concentrations in the plasma, hippocampus, hypothalamus and adrenal gland using ELISA and iodine-125-labeled recombinant human IL-1alpha ([(125)I]IL-1alpha) binding in the hippocampus following the intraperitoneal administration of saline or LPS.There were no significant differences in the concentrations of IL-1beta and its receptors in the brain and peripheral tissues between sham-operated and ODX mice in both age groups injected with saline. LPS induced significantly higher IL-1beta production in the plasma and hippocampus in sham-operated 24-week-old mice than in 7-week-old mice. Coincident with the heightened IL-1beta response to LPS, hippocampal [(125)I]IL-1alpha binding was lower in 24-week-old mice than in 7-week-old mice after LPS injection in the sham-operated group. The age-related differences in the IL-1beta concentrations in the plasma and hippocampus and [(125)I]IL-1alpha binding in the hippocampus in response to LPS administration were abolished by ODX. Although LPS dramatically increased IL-1beta levels in the hypothalamus, no significant age-related differences in IL-1beta concentrations were seen, and ODX did not affect IL-1beta levels. In contrast, there were no significant differences between saline- and LPS-injected 7-week-old mice in relation to concentrations in the adrenal gland. Moreover, although the adrenal IL-1beta concentrations in 24-week-old mice were significantly higher than those in 7-week-old mice, ODX did not abolish these age-related differences in concentrations in the adrenal gland.Our data suggest the involvement of testosterone (or gonadal product) in plasma and hippocampal IL-1beta regulation in relation to age, and demonstrate the importance of the gonadal development in mediating the effects of infectious challenge on the brain and immune function." @default.
• W2018406848 created "2016-06-24" @default.
• W2018406848 creator A5001289811 @default.
• W2018406848 creator A5036277796 @default.
• W2018406848 creator A5045586814 @default.
• W2018406848 creator A5078598537 @default.
• W2018406848 creator A5090425337 @default.
• W2018406848 date "2000-01-01" @default.
• W2018406848 modified "2023-10-14" @default.
• W2018406848 title "Effect of Orchidectomy on the Age-Related Modulation of IL-1β and IL-1 Receptors following Lipopolysaccharide Treatment in the Mouse" @default.
• W2018406848 cites W1526265727 @default.
• W2018406848 cites W1604316703 @default.
• W2018406848 cites W1848552725 @default.
• W2018406848 cites W1965283209 @default.
• W2018406848 cites W1968713831 @default.
• W2018406848 cites W1969309241 @default.
• W2018406848 cites W1972993926 @default.
• W2018406848 cites W1980356204 @default.
• W2018406848 cites W1988311866 @default.
• W2018406848 cites W1990903699 @default.
• W2018406848 cites W1991653799 @default.
• W2018406848 cites W2000956334 @default.
• W2018406848 cites W2006587144 @default.
• W2018406848 cites W2008261126 @default.
• W2018406848 cites W2014484891 @default.
• W2018406848 cites W2014689988 @default.
• W2018406848 cites W2027625619 @default.
• W2018406848 cites W2029027714 @default.
• W2018406848 cites W2031055782 @default.
• W2018406848 cites W2034137314 @default.
• W2018406848 cites W2036978149 @default.
• W2018406848 cites W2038162032 @default.
• W2018406848 cites W2043085884 @default.
• W2018406848 cites W2046123379 @default.
• W2018406848 cites W2048938503 @default.
• W2018406848 cites W2056230880 @default.
• W2018406848 cites W2069132198 @default.
• W2018406848 cites W2073883348 @default.
• W2018406848 cites W2073977304 @default.
• W2018406848 cites W2076739340 @default.
• W2018406848 cites W2080025220 @default.
• W2018406848 cites W2108690804 @default.
• W2018406848 cites W2145865543 @default.
• W2018406848 cites W2145890122 @default.
• W2018406848 cites W2148439332 @default.
• W2018406848 cites W2165636895 @default.
• W2018406848 cites W2400326620 @default.
• W2018406848 cites W2414379972 @default.
• W2018406848 cites W67521496 @default.
• W2018406848 doi "https://doi.org/10.1159/000026447" @default.
• W2018406848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10859483" @default.
• W2018406848 hasPublicationYear "2000" @default.
• W2018406848 type Work @default.
• W2018406848 sameAs 2018406848 @default.
• W2018406848 citedByCount "5" @default.
• W2018406848 crossrefType "journal-article" @default.
• W2018406848 hasAuthorship W2018406848A5001289811 @default.
• W2018406848 hasAuthorship W2018406848A5036277796 @default.
• W2018406848 hasAuthorship W2018406848A5045586814 @default.
• W2018406848 hasAuthorship W2018406848A5078598537 @default.
• W2018406848 hasAuthorship W2018406848A5090425337 @default.
• W2018406848 hasConcept C11988809 @default.
• W2018406848 hasConcept C126322002 @default.
• W2018406848 hasConcept C134018914 @default.
• W2018406848 hasConcept C148762608 @default.
• W2018406848 hasConcept C170493617 @default.
• W2018406848 hasConcept C2776885963 @default.
• W2018406848 hasConcept C2777003273 @default.
• W2018406848 hasConcept C2777397205 @default.
• W2018406848 hasConcept C2778122271 @default.
• W2018406848 hasConcept C2778690821 @default.
• W2018406848 hasConcept C2778754761 @default.
• W2018406848 hasConcept C2780159080 @default.
• W2018406848 hasConcept C2781161787 @default.
• W2018406848 hasConcept C71924100 @default.
• W2018406848 hasConcept C74172505 @default.
• W2018406848 hasConceptScore W2018406848C11988809 @default.
• W2018406848 hasConceptScore W2018406848C126322002 @default.
• W2018406848 hasConceptScore W2018406848C134018914 @default.
• W2018406848 hasConceptScore W2018406848C148762608 @default.
• W2018406848 hasConceptScore W2018406848C170493617 @default.
• W2018406848 hasConceptScore W2018406848C2776885963 @default.
• W2018406848 hasConceptScore W2018406848C2777003273 @default.
• W2018406848 hasConceptScore W2018406848C2777397205 @default.
• W2018406848 hasConceptScore W2018406848C2778122271 @default.
• W2018406848 hasConceptScore W2018406848C2778690821 @default.
• W2018406848 hasConceptScore W2018406848C2778754761 @default.
• W2018406848 hasConceptScore W2018406848C2780159080 @default.
• W2018406848 hasConceptScore W2018406848C2781161787 @default.
• W2018406848 hasConceptScore W2018406848C71924100 @default.
• W2018406848 hasConceptScore W2018406848C74172505 @default.
• W2018406848 hasLocation W20184068481 @default.
• W2018406848 hasLocation W20184068482 @default.
• W2018406848 hasOpenAccess W2018406848 @default.
• W2018406848 hasPrimaryLocation W20184068481 @default.
• W2018406848 hasRelatedWork W1981622392 @default.
• W2018406848 hasRelatedWork W1991926339 @default.
• W2018406848 hasRelatedWork W2016312856 @default.
• W2018406848 hasRelatedWork W2027625619 @default.
• W2018406848 hasRelatedWork W2030461772 @default.

• next