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- W2018408184 abstract "The use-dependent decrease in maximum upstroke velocity (Vmax) caused by RS-2135, a new antiarrhythmic compound was analyzed in isolated papillary muscles of guinea pigs. RS-2135 3 and 10 μM decreased Vmax of action potential (AP) in a concentration-related manner without affecting resting membrane potential (RMP). Vmax decay in the presence of RS-2135 was exponential at stimulation rates ≥ 0.5 Hz. This use-dependent block of Vmax was enhanced at higher stimulation frequencies. The time constants and onset rates per action potential of the use-dependent block were 10.7 26.9 s and 0.021–0.041 AP-1, respectively. The time constants of recovery from use-dependent block were 57.9 and 63.6 s, respectively, in the presence of 3 and 10 μM RS-2135. The predicted half-time of the recovery process calculated by physicochemical parameters of RS-2135 agreed well with the observed values. These results suggest that RS-2135 is a sodium channel blocking agent with slow kinetics and that the physicochemical properties underlie these characteristics." @default.
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- W2018408184 date "1993-03-01" @default.
- W2018408184 modified "2023-09-25" @default.
- W2018408184 title "Effects of RS-2135, a New Antiarrhythmic Agent, on the Kinetics of Use-Dependent Decrease in Maximum Upstroke Velocity in Guinea Pig Ventricular Myocardium" @default.
- W2018408184 doi "https://doi.org/10.1097/00005344-199303000-00012" @default.
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