Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018411908> ?p ?o ?g. }
- W2018411908 endingPage "430" @default.
- W2018411908 startingPage "424" @default.
- W2018411908 abstract "Skin contact has been hypothesized to contribute to human exposure to bisphenol A (BPA). We examined the diffusion and metabolism of BPA using viable skin models: human skin explants and short-term cultures of pig ear skin, an alternative model for the study of the fate of xenobiotics following contact exposure. 14C-BPA [50–800 nmol] was applied on the surface of skin models. Radioactivity distribution was measured in all skin compartments and in the diffusion cells of static cells diffusion systems. BPA and metabolites were further quantified by radio-HPLC. BPA was efficiently absorbed in short-term cultures, with no major difference between the models used in the study [viable pig ear skin: 65%; viable human explants: 46%; non-viable (previously frozen) pig skin: 58%]. BPA was extensively metabolized in viable systems only. Major BPA metabolites produced by the skin were BPA mono-glucuronide and BPA mono-sulfate, accounting together for 73% and 27% of the dose, in pig and human, respectively. In conclusion, experiments with viable skin models unequivocally demonstrate that BPA is readily absorbed and metabolized by the skin. The trans-dermal route is expected to contribute substantially to BPA exposure in human, when direct contact with BPA (free monomer) occurs." @default.
- W2018411908 created "2016-06-24" @default.
- W2018411908 creator A5041104380 @default.
- W2018411908 creator A5042821141 @default.
- W2018411908 creator A5064780645 @default.
- W2018411908 creator A5080064158 @default.
- W2018411908 creator A5080829078 @default.
- W2018411908 date "2011-01-01" @default.
- W2018411908 modified "2023-10-10" @default.
- W2018411908 title "Viable skin efficiently absorbs and metabolizes bisphenol A" @default.
- W2018411908 cites W1497761327 @default.
- W2018411908 cites W1523272829 @default.
- W2018411908 cites W1965431334 @default.
- W2018411908 cites W1967211742 @default.
- W2018411908 cites W1970358298 @default.
- W2018411908 cites W1979440858 @default.
- W2018411908 cites W1982173229 @default.
- W2018411908 cites W1982477373 @default.
- W2018411908 cites W1998322977 @default.
- W2018411908 cites W2013402699 @default.
- W2018411908 cites W2015497299 @default.
- W2018411908 cites W2032832284 @default.
- W2018411908 cites W2036815885 @default.
- W2018411908 cites W2041719197 @default.
- W2018411908 cites W2043305460 @default.
- W2018411908 cites W2049094561 @default.
- W2018411908 cites W2055368979 @default.
- W2018411908 cites W2060297397 @default.
- W2018411908 cites W2061135914 @default.
- W2018411908 cites W2063517792 @default.
- W2018411908 cites W2071555629 @default.
- W2018411908 cites W2080672859 @default.
- W2018411908 cites W2081746977 @default.
- W2018411908 cites W2083033154 @default.
- W2018411908 cites W2090047145 @default.
- W2018411908 cites W2100846538 @default.
- W2018411908 cites W2111417994 @default.
- W2018411908 cites W2113644293 @default.
- W2018411908 cites W2114729638 @default.
- W2018411908 cites W2136799713 @default.
- W2018411908 cites W2148722053 @default.
- W2018411908 cites W2151572760 @default.
- W2018411908 cites W2152312983 @default.
- W2018411908 cites W2154180503 @default.
- W2018411908 cites W4237790777 @default.
- W2018411908 doi "https://doi.org/10.1016/j.chemosphere.2010.09.058" @default.
- W2018411908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21030062" @default.
- W2018411908 hasPublicationYear "2011" @default.
- W2018411908 type Work @default.
- W2018411908 sameAs 2018411908 @default.
- W2018411908 citedByCount "207" @default.
- W2018411908 countsByYear W20184119082012 @default.
- W2018411908 countsByYear W20184119082013 @default.
- W2018411908 countsByYear W20184119082014 @default.
- W2018411908 countsByYear W20184119082015 @default.
- W2018411908 countsByYear W20184119082016 @default.
- W2018411908 countsByYear W20184119082017 @default.
- W2018411908 countsByYear W20184119082018 @default.
- W2018411908 countsByYear W20184119082019 @default.
- W2018411908 countsByYear W20184119082020 @default.
- W2018411908 countsByYear W20184119082021 @default.
- W2018411908 countsByYear W20184119082022 @default.
- W2018411908 countsByYear W20184119082023 @default.
- W2018411908 crossrefType "journal-article" @default.
- W2018411908 hasAuthorship W2018411908A5041104380 @default.
- W2018411908 hasAuthorship W2018411908A5042821141 @default.
- W2018411908 hasAuthorship W2018411908A5064780645 @default.
- W2018411908 hasAuthorship W2018411908A5080064158 @default.
- W2018411908 hasAuthorship W2018411908A5080829078 @default.
- W2018411908 hasBestOaLocation W20184119082 @default.
- W2018411908 hasConcept C115448650 @default.
- W2018411908 hasConcept C166595027 @default.
- W2018411908 hasConcept C178790620 @default.
- W2018411908 hasConcept C181199279 @default.
- W2018411908 hasConcept C185592680 @default.
- W2018411908 hasConcept C195289149 @default.
- W2018411908 hasConcept C2777459323 @default.
- W2018411908 hasConcept C2779684741 @default.
- W2018411908 hasConcept C43617362 @default.
- W2018411908 hasConcept C54355233 @default.
- W2018411908 hasConcept C55493867 @default.
- W2018411908 hasConcept C62231903 @default.
- W2018411908 hasConcept C86803240 @default.
- W2018411908 hasConceptScore W2018411908C115448650 @default.
- W2018411908 hasConceptScore W2018411908C166595027 @default.
- W2018411908 hasConceptScore W2018411908C178790620 @default.
- W2018411908 hasConceptScore W2018411908C181199279 @default.
- W2018411908 hasConceptScore W2018411908C185592680 @default.
- W2018411908 hasConceptScore W2018411908C195289149 @default.
- W2018411908 hasConceptScore W2018411908C2777459323 @default.
- W2018411908 hasConceptScore W2018411908C2779684741 @default.
- W2018411908 hasConceptScore W2018411908C43617362 @default.
- W2018411908 hasConceptScore W2018411908C54355233 @default.
- W2018411908 hasConceptScore W2018411908C55493867 @default.
- W2018411908 hasConceptScore W2018411908C62231903 @default.
- W2018411908 hasConceptScore W2018411908C86803240 @default.
- W2018411908 hasIssue "3" @default.
- W2018411908 hasLocation W20184119081 @default.