FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018421719> ?p ?o ?g. }

• W2018421719 endingPage "2305" @default.
• W2018421719 startingPage "2295" @default.
• W2018421719 abstract "Abstract During the past decade, novel disposable cell culture vessels (generally referred to as Process Scouting Devices or PSDs) have become increasingly popular for laboratory scale studies and seed culture generation. However, the lack of engineering characterization and online monitoring tools for PSDs makes it difficult to elucidate their oxygen transfer capabilities. In this study, a mass transfer characterization ( k L a ) of sensor enabled static and rocking T‐flasks is presented and compared with other non‐instrumented PSDs such as CultiFlask 50®, spinner flasks, and SuperSpinner D 1000®. We have also developed a mass transfer empirical correlation that accounts for the contribution of convection and diffusion to the volumetric mass transfer coefficient ( k L a ) in rocking T‐flasks. We also carried out a scale‐down study at matched k L a between a rocking T75‐flask and a 10 L (2 L filling volume) wave bioreactor (Cultibag®) and we observed similar DO and pH profiles as well as maximum cell density and protein titer. However, in this scale‐down study, we also observed a negative correlation between cell growth and protein productivity between the rocking T‐flask and the wave bioreactor. We hypothesize that this negative correlation can be due to hydrodynamic stress difference between the rocking T‐flask and the Cultibag. As both cell culture devices share key similarities such as type of agitation (i.e., rocking), oxygen transfer capabilities (i.e., k L a ) and disposability, we argue that rocking T‐flasks can be readily integrated with wave bioreactors, making the transition from research‐scale to manufacturing‐scale a seamless process. Biotechnol. Bioeng. 2012;109: 2295–2305. © 2012 Wiley Periodicals, Inc." @default.
• W2018421719 created "2016-06-24" @default.
• W2018421719 creator A5002013224 @default.
• W2018421719 creator A5007095296 @default.
• W2018421719 creator A5021098447 @default.
• W2018421719 creator A5050140316 @default.
• W2018421719 creator A5078263161 @default.
• W2018421719 date "2012-04-11" @default.
• W2018421719 modified "2023-10-11" @default.
• W2018421719 title "Optical sensor enabled rocking T-flasks as novel upstream bioprocessing tools" @default.
• W2018421719 cites W1487252915 @default.
• W2018421719 cites W1965876945 @default.
• W2018421719 cites W1981837778 @default.
• W2018421719 cites W1987788000 @default.
• W2018421719 cites W1991372299 @default.
• W2018421719 cites W1992216853 @default.
• W2018421719 cites W2002491932 @default.
• W2018421719 cites W2012276721 @default.
• W2018421719 cites W2013276474 @default.
• W2018421719 cites W2014197812 @default.
• W2018421719 cites W2015481043 @default.
• W2018421719 cites W2033040421 @default.
• W2018421719 cites W2037942078 @default.
• W2018421719 cites W2045439749 @default.
• W2018421719 cites W2046308467 @default.
• W2018421719 cites W2052785920 @default.
• W2018421719 cites W2055200763 @default.
• W2018421719 cites W2071988873 @default.
• W2018421719 cites W2084454500 @default.
• W2018421719 cites W2092564795 @default.
• W2018421719 cites W2096983081 @default.
• W2018421719 cites W2106430658 @default.
• W2018421719 cites W2107031198 @default.
• W2018421719 cites W2146230665 @default.
• W2018421719 cites W2146402498 @default.
• W2018421719 cites W2146836367 @default.
• W2018421719 cites W2152850495 @default.
• W2018421719 cites W2153707479 @default.
• W2018421719 cites W2169569849 @default.
• W2018421719 cites W3158881214 @default.
• W2018421719 doi "https://doi.org/10.1002/bit.24508" @default.
• W2018421719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22473759" @default.
• W2018421719 hasPublicationYear "2012" @default.
• W2018421719 type Work @default.
• W2018421719 sameAs 2018421719 @default.
• W2018421719 citedByCount "6" @default.
• W2018421719 countsByYear W20184217192012 @default.
• W2018421719 countsByYear W20184217192016 @default.
• W2018421719 countsByYear W20184217192018 @default.
• W2018421719 countsByYear W20184217192019 @default.
• W2018421719 countsByYear W20184217192021 @default.
• W2018421719 crossrefType "journal-article" @default.
• W2018421719 hasAuthorship W2018421719A5002013224 @default.
• W2018421719 hasAuthorship W2018421719A5007095296 @default.
• W2018421719 hasAuthorship W2018421719A5021098447 @default.
• W2018421719 hasAuthorship W2018421719A5050140316 @default.
• W2018421719 hasAuthorship W2018421719A5078263161 @default.
• W2018421719 hasConcept C101555633 @default.
• W2018421719 hasConcept C113196181 @default.
• W2018421719 hasConcept C121332964 @default.
• W2018421719 hasConcept C127413603 @default.
• W2018421719 hasConcept C139149728 @default.
• W2018421719 hasConcept C147789679 @default.
• W2018421719 hasConcept C168170006 @default.
• W2018421719 hasConcept C178790620 @default.
• W2018421719 hasConcept C185592680 @default.
• W2018421719 hasConcept C192562407 @default.
• W2018421719 hasConcept C20556612 @default.
• W2018421719 hasConcept C42360764 @default.
• W2018421719 hasConcept C43617362 @default.
• W2018421719 hasConcept C4916135 @default.
• W2018421719 hasConcept C51038369 @default.
• W2018421719 hasConcept C97355855 @default.
• W2018421719 hasConceptScore W2018421719C101555633 @default.
• W2018421719 hasConceptScore W2018421719C113196181 @default.
• W2018421719 hasConceptScore W2018421719C121332964 @default.
• W2018421719 hasConceptScore W2018421719C127413603 @default.
• W2018421719 hasConceptScore W2018421719C139149728 @default.
• W2018421719 hasConceptScore W2018421719C147789679 @default.
• W2018421719 hasConceptScore W2018421719C168170006 @default.
• W2018421719 hasConceptScore W2018421719C178790620 @default.
• W2018421719 hasConceptScore W2018421719C185592680 @default.
• W2018421719 hasConceptScore W2018421719C192562407 @default.
• W2018421719 hasConceptScore W2018421719C20556612 @default.
• W2018421719 hasConceptScore W2018421719C42360764 @default.
• W2018421719 hasConceptScore W2018421719C43617362 @default.
• W2018421719 hasConceptScore W2018421719C4916135 @default.
• W2018421719 hasConceptScore W2018421719C51038369 @default.
• W2018421719 hasConceptScore W2018421719C97355855 @default.
• W2018421719 hasIssue "9" @default.
• W2018421719 hasLocation W20184217191 @default.
• W2018421719 hasLocation W20184217192 @default.
• W2018421719 hasOpenAccess W2018421719 @default.
• W2018421719 hasPrimaryLocation W20184217191 @default.
• W2018421719 hasRelatedWork W1560460200 @default.
• W2018421719 hasRelatedWork W1992876438 @default.
• W2018421719 hasRelatedWork W2007171904 @default.
• W2018421719 hasRelatedWork W2009118295 @default.

• next