Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018427238> ?p ?o ?g. }
- W2018427238 endingPage "1018" @default.
- W2018427238 startingPage "1006" @default.
- W2018427238 abstract "Extracellular proteins are vital for cell activities, such as cell migration. Calumenin is highly conserved among eukaryotes, but its functions are largely unclear. Here, we identify extracellular calumenin as a suppressor of cell migration and tumor metastasis. Calumenin binds to and stabilizes fibulin-1, leading to inactivation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling. We further identify the minimal functional domain of calumenin (amino acids 74-138 and 214-280). Depletion of calumenin induces fibulin-1- and phospho-ERK1/2 (pERK1/2)-dependent promotion of cell migration. Consistently, in hepatocellular and pancreatic carcinoma, both calumenin and fibulin-1 are downregulated. Furthermore, we show that matrix metalloproteinase-13 (MMP-13) proteolyzes fibulin-1 and that calumenin protects fibulin-1 from cleavage by MMP-13. Calumenin, together with fibulin-1, also interacts with fibronectin and depends on both syndecan-4 and α5β1-integrin to suppress ERK1/2 signaling and inhibit cell migration. Thus, extracellular calumenin regulates fibulin-1 to have crucial roles in ERK1/2 signaling and cell migration." @default.
- W2018427238 created "2016-06-24" @default.
- W2018427238 creator A5001291862 @default.
- W2018427238 creator A5007488932 @default.
- W2018427238 creator A5013341573 @default.
- W2018427238 creator A5013951534 @default.
- W2018427238 creator A5033241557 @default.
- W2018427238 creator A5036773185 @default.
- W2018427238 creator A5048048280 @default.
- W2018427238 creator A5060887077 @default.
- W2018427238 creator A5062513274 @default.
- W2018427238 creator A5064677712 @default.
- W2018427238 creator A5079546581 @default.
- W2018427238 date "2014-03-17" @default.
- W2018427238 modified "2023-10-18" @default.
- W2018427238 title "Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis" @default.
- W2018427238 cites W1555862556 @default.
- W2018427238 cites W1950988583 @default.
- W2018427238 cites W1972250033 @default.
- W2018427238 cites W1974478155 @default.
- W2018427238 cites W1974828804 @default.
- W2018427238 cites W1980506609 @default.
- W2018427238 cites W1986848694 @default.
- W2018427238 cites W1989480741 @default.
- W2018427238 cites W1989970584 @default.
- W2018427238 cites W2002348026 @default.
- W2018427238 cites W2002764286 @default.
- W2018427238 cites W2005334224 @default.
- W2018427238 cites W2006353558 @default.
- W2018427238 cites W2008920115 @default.
- W2018427238 cites W2012162957 @default.
- W2018427238 cites W2014350034 @default.
- W2018427238 cites W2019966970 @default.
- W2018427238 cites W2022825062 @default.
- W2018427238 cites W2026632078 @default.
- W2018427238 cites W2033100064 @default.
- W2018427238 cites W2033745068 @default.
- W2018427238 cites W2036137501 @default.
- W2018427238 cites W2040196938 @default.
- W2018427238 cites W2042476998 @default.
- W2018427238 cites W2043013160 @default.
- W2018427238 cites W2054762295 @default.
- W2018427238 cites W2058258724 @default.
- W2018427238 cites W2062278312 @default.
- W2018427238 cites W2063155653 @default.
- W2018427238 cites W2064077005 @default.
- W2018427238 cites W2064297038 @default.
- W2018427238 cites W2066828652 @default.
- W2018427238 cites W2072595668 @default.
- W2018427238 cites W2074239088 @default.
- W2018427238 cites W2074998492 @default.
- W2018427238 cites W2086386116 @default.
- W2018427238 cites W2088890582 @default.
- W2018427238 cites W2094114923 @default.
- W2018427238 cites W2094875212 @default.
- W2018427238 cites W2100625668 @default.
- W2018427238 cites W2107277218 @default.
- W2018427238 cites W2108447763 @default.
- W2018427238 cites W2112874194 @default.
- W2018427238 cites W2117692326 @default.
- W2018427238 cites W2118937590 @default.
- W2018427238 cites W2127217749 @default.
- W2018427238 cites W2136704317 @default.
- W2018427238 cites W2139043430 @default.
- W2018427238 cites W2139130671 @default.
- W2018427238 cites W2142375040 @default.
- W2018427238 cites W2148616604 @default.
- W2018427238 cites W2166063947 @default.
- W2018427238 cites W2168650364 @default.
- W2018427238 cites W271570111 @default.
- W2018427238 doi "https://doi.org/10.1038/onc.2014.52" @default.
- W2018427238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24632605" @default.
- W2018427238 hasPublicationYear "2014" @default.
- W2018427238 type Work @default.
- W2018427238 sameAs 2018427238 @default.
- W2018427238 citedByCount "32" @default.
- W2018427238 countsByYear W20184272382015 @default.
- W2018427238 countsByYear W20184272382016 @default.
- W2018427238 countsByYear W20184272382017 @default.
- W2018427238 countsByYear W20184272382018 @default.
- W2018427238 countsByYear W20184272382019 @default.
- W2018427238 countsByYear W20184272382020 @default.
- W2018427238 countsByYear W20184272382021 @default.
- W2018427238 countsByYear W20184272382022 @default.
- W2018427238 countsByYear W20184272382023 @default.
- W2018427238 crossrefType "journal-article" @default.
- W2018427238 hasAuthorship W2018427238A5001291862 @default.
- W2018427238 hasAuthorship W2018427238A5007488932 @default.
- W2018427238 hasAuthorship W2018427238A5013341573 @default.
- W2018427238 hasAuthorship W2018427238A5013951534 @default.
- W2018427238 hasAuthorship W2018427238A5033241557 @default.
- W2018427238 hasAuthorship W2018427238A5036773185 @default.
- W2018427238 hasAuthorship W2018427238A5048048280 @default.
- W2018427238 hasAuthorship W2018427238A5060887077 @default.
- W2018427238 hasAuthorship W2018427238A5062513274 @default.
- W2018427238 hasAuthorship W2018427238A5064677712 @default.
- W2018427238 hasAuthorship W2018427238A5079546581 @default.
- W2018427238 hasBestOaLocation W20184272381 @default.