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• W2018431021 startingPage "974" @default.
• W2018431021 abstract "Perfluorochemicals are globally pervasive contaminants that are persistent, bioaccumulative, and toxic. Perfluorocarboxylic acids (PFCAs) with 8−13 carbons accumulate in the liver and blood of aquatic organisms; PFCA−protein interactions may explain this accumulation pattern. Here, the interactions between PFCAs with 8−11 carbons and serum albumin are examined using three experimental approaches: surface tension titrations, 19F NMR spectroscopy, and fluorescence spectroscopy. Surface tension titrations indicate complex formation at high (mM) PFCA concentrations. Secondary association constants ranging from 102 to 104 M−1 were determined from 19F NMR titrations at high PFCA:albumin mole ratios. Fluorescence measurements indicate that PFCA−albumin interactions alter the protein conformation at low PFCA:albumin mole ratios (up to 5:1) and suggest two binding classes with association constants around 105 and 102 M−1. While 19F NMR and fluorescence provide both qualitative and quantitative information about PFCA−albumin interactions, surface tension provides only qualitative information. Limitations associated with instrumentation and methods require high PFCA concentrations in both surface tension and 19F NMR experiments; in contrast, fluorescence allows for analysis of a wider range of PFCA concentrations and PFCA:albumin mole ratios. Results from this study indicate that fluorescence, though an indirect method, offers a more comprehensive picture of the nature of PFCA−albumin interactions." @default.
• W2018431021 created "2016-06-24" @default.
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• W2018431021 date "2009-12-29" @default.
• W2018431021 modified "2023-10-16" @default.
• W2018431021 title "Binding of Perfluorocarboxylates to Serum Albumin: A Comparison of Analytical Methods" @default.
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• W2018431021 doi "https://doi.org/10.1021/ac902238u" @default.
• W2018431021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20039637" @default.
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