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• W2018431023 abstract "A strategy for targeting protein kinases with large ATP-binding sites by using bulky and rigid octahedral ruthenium complexes as structural scaffolds is presented. A highly potent and selective GSK3 and Pim1 half-sandwich complex NP309 was successfully converted into a PAK1 inhibitor by making use of the large octahedral compounds Λ-FL172 and Λ-FL411 in which the cyclopentadienyl moiety of NP309 is replaced by a chloride and sterically demanding diimine ligands. A 1.65 Å cocrystal structure of PAK1 with Λ-FL172 reveals how the large coordination sphere of the ruthenium complex matches the size of the active site and serves as a yardstick to discriminate between otherwise closely related binding sites." @default.
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• W2018431023 date "2008-10-31" @default.
• W2018431023 modified "2023-10-12" @default.
• W2018431023 title "Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes" @default.
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• W2018431023 doi "https://doi.org/10.1021/ja805555a" @default.
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