Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018439497> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2018439497 abstract "One pathological effect of polyglutamine (polyQ) diseases, such as Huntington's disease, is the aggregation of polyQ tracts in nerve cells. These aggregates form larger fibrils in the cells called inclusions. Though the exact pathological role these inclusions play is unknown, an increase in their development is directly correlated to progression of these diseases. The solution structure and aggregation mechanism of polyQ aggregates is poorly understood and, consequently, is a subject of interest in the biophysics community. Understanding the conformational stability and dynamic properties of polyQ peptides is an important component along the path towards pathological polyQ aggregation. Metadynamics simulation was used to explore the energy landscape of DD(Q)17KK peptides in vacuum, implicit and explicit solvent environments. Initial results from the implicit solvent simulations yield an energy landscape populated by extended and hairpin structures. The results from all simulations will be presented." @default.
- W2018439497 created "2016-06-24" @default.
- W2018439497 creator A5003571956 @default.
- W2018439497 creator A5036387253 @default.
- W2018439497 date "2013-01-01" @default.
- W2018439497 modified "2023-09-26" @default.
- W2018439497 title "The Conformational Energy Landscape of Aqueous Polyglutamine Peptides from Metadynamics Calculations" @default.
- W2018439497 doi "https://doi.org/10.1016/j.bpj.2012.11.958" @default.
- W2018439497 hasPublicationYear "2013" @default.
- W2018439497 type Work @default.
- W2018439497 sameAs 2018439497 @default.
- W2018439497 citedByCount "0" @default.
- W2018439497 crossrefType "journal-article" @default.
- W2018439497 hasAuthorship W2018439497A5003571956 @default.
- W2018439497 hasAuthorship W2018439497A5036387253 @default.
- W2018439497 hasBestOaLocation W20184394971 @default.
- W2018439497 hasConcept C119621388 @default.
- W2018439497 hasConcept C121332964 @default.
- W2018439497 hasConcept C12554922 @default.
- W2018439497 hasConcept C134121241 @default.
- W2018439497 hasConcept C136238340 @default.
- W2018439497 hasConcept C147597530 @default.
- W2018439497 hasConcept C148093993 @default.
- W2018439497 hasConcept C159467904 @default.
- W2018439497 hasConcept C185592680 @default.
- W2018439497 hasConcept C27523624 @default.
- W2018439497 hasConcept C2779455329 @default.
- W2018439497 hasConcept C2780471494 @default.
- W2018439497 hasConcept C55493867 @default.
- W2018439497 hasConcept C59593255 @default.
- W2018439497 hasConcept C62752575 @default.
- W2018439497 hasConcept C86803240 @default.
- W2018439497 hasConcept C97355855 @default.
- W2018439497 hasConceptScore W2018439497C119621388 @default.
- W2018439497 hasConceptScore W2018439497C121332964 @default.
- W2018439497 hasConceptScore W2018439497C12554922 @default.
- W2018439497 hasConceptScore W2018439497C134121241 @default.
- W2018439497 hasConceptScore W2018439497C136238340 @default.
- W2018439497 hasConceptScore W2018439497C147597530 @default.
- W2018439497 hasConceptScore W2018439497C148093993 @default.
- W2018439497 hasConceptScore W2018439497C159467904 @default.
- W2018439497 hasConceptScore W2018439497C185592680 @default.
- W2018439497 hasConceptScore W2018439497C27523624 @default.
- W2018439497 hasConceptScore W2018439497C2779455329 @default.
- W2018439497 hasConceptScore W2018439497C2780471494 @default.
- W2018439497 hasConceptScore W2018439497C55493867 @default.
- W2018439497 hasConceptScore W2018439497C59593255 @default.
- W2018439497 hasConceptScore W2018439497C62752575 @default.
- W2018439497 hasConceptScore W2018439497C86803240 @default.
- W2018439497 hasConceptScore W2018439497C97355855 @default.
- W2018439497 hasLocation W20184394971 @default.
- W2018439497 hasOpenAccess W2018439497 @default.
- W2018439497 hasPrimaryLocation W20184394971 @default.
- W2018439497 hasRelatedWork W1988038897 @default.
- W2018439497 hasRelatedWork W1990443320 @default.
- W2018439497 hasRelatedWork W1992390250 @default.
- W2018439497 hasRelatedWork W2017754448 @default.
- W2018439497 hasRelatedWork W2019307292 @default.
- W2018439497 hasRelatedWork W2023700994 @default.
- W2018439497 hasRelatedWork W2030753289 @default.
- W2018439497 hasRelatedWork W2040995211 @default.
- W2018439497 hasRelatedWork W2043740558 @default.
- W2018439497 hasRelatedWork W2120531463 @default.
- W2018439497 hasRelatedWork W2137373119 @default.
- W2018439497 hasRelatedWork W2231187861 @default.
- W2018439497 hasRelatedWork W2237653326 @default.
- W2018439497 hasRelatedWork W2260156171 @default.
- W2018439497 hasRelatedWork W2292896090 @default.
- W2018439497 hasRelatedWork W2318414036 @default.
- W2018439497 hasRelatedWork W2919674238 @default.
- W2018439497 hasRelatedWork W2991318137 @default.
- W2018439497 hasRelatedWork W3095688313 @default.
- W2018439497 hasRelatedWork W3197991050 @default.
- W2018439497 isParatext "false" @default.
- W2018439497 isRetracted "false" @default.
- W2018439497 magId "2018439497" @default.
- W2018439497 workType "article" @default.