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- W2018444997 abstract "Here, we describe a new paradigm for the development of small molecule-based RNA sensors. We prepared a series of potential PET (photoinduced electron transfer) sensors on the basis of 2',7'-dichlorofluorescein (DCF) fluorophore conjugated with two aniline derivatives as electron donors (quenchers). NMR and fluorescent spectroscopic analyses of these DCF derivatives revealed the correlation between the conformations, the PET, and the fluorescent intensities of these DCF derivatives, enabling us to select a sensor candidate. RNA aptamers were raised against the aniline-based quencher via in vitro selection (SELEX). One of these aptamers enhanced the fluorescence intensity of the DCF-aniline conjugate in a concentration-dependent manner. To demonstrate the power and generality of this approach, additional in vitro selection was performed and aptamers from this selection were found to have similar activities. These results show that one can develop fluorescence-inducing reporter RNA and morph it into remotely related sequences without prior structural insight into RNA-ligand binding." @default.
- W2018444997 created "2016-06-24" @default.
- W2018444997 creator A5051539270 @default.
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- W2018444997 date "2007-03-27" @default.
- W2018444997 modified "2023-10-14" @default.
- W2018444997 title "Fluorescent Sensors for Specific RNA: A General Paradigm Using Chemistry and Combinatorial Biology" @default.
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- W2018444997 doi "https://doi.org/10.1021/ja070111z" @default.
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