Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018446429> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2018446429 abstract "The inositiol 1,4,5 trisphospate receptor (InsP3R), an intracellular calcium channel, is a family of three isoforms. All three isoforms display a significant level of sequence identity yet they differ in expression level, localization and many functional aspects. We previously showed that InsP3R type 1 is modified by O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylated). Through this dynamic and inducible modification a single monosaccharide is covalently attached to serine and threonine residues of the protein backbone, providing protein regulation similar to O-phosphorylation. We also reported that increased O-GlcNAcylation of the InsP3R type 1 reduced the percent of cells that responded to addition of extracellular agonists and those that did respond had a decreased InsP3 dependent calcium release from the endoplasmic reticulum (ER). We now report that the InsP3R type 3 is also O-GlcNAcylated. Interestingly, the functional impact of O-GlcNAcylation on InsP3R type 3 channel is opposite to the effect measured with the InsP3R type 1. Human cholangiocytoma cells (MzChA-1) contain >90% InsP3R type 3. When these cells were incubated in hyperglycemic media there was an increase in the percent cells responding to InsP3 generating stimuli and there was an increase in the InsP3 dependent calcium release from the ER. A difference in functional response between InsP3R isoforms was reported previously for phosphorylation by cyclic AMP dependent protein kinase (PKA). In contrast, the InsP3R type 2 showed no detectable O-GlcNAc glycosylation and no significant functional changes even though the enzymes necessary for both the addition and removal of the monosccharide are present in all cell types tested. The dynamic and inducible nature of O-GlcNAcylation and the isoform specificity suggests that this form of modification of the InsP3R and subsequent changes in intracellular calcium transients will be important in physiological and pathophysiological processes." @default.
- W2018446429 created "2016-06-24" @default.
- W2018446429 creator A5011927466 @default.
- W2018446429 creator A5024761796 @default.
- W2018446429 creator A5030261371 @default.
- W2018446429 creator A5072111063 @default.
- W2018446429 creator A5088629560 @default.
- W2018446429 date "2009-02-01" @default.
- W2018446429 modified "2023-09-29" @default.
- W2018446429 title "Regulation Of Inositol 1,4,5-Trisphosphate Receptor Isoforms By O-Linked Glycosylation" @default.
- W2018446429 doi "https://doi.org/10.1016/j.bpj.2008.12.412" @default.
- W2018446429 hasPublicationYear "2009" @default.
- W2018446429 type Work @default.
- W2018446429 sameAs 2018446429 @default.
- W2018446429 citedByCount "0" @default.
- W2018446429 crossrefType "journal-article" @default.
- W2018446429 hasAuthorship W2018446429A5011927466 @default.
- W2018446429 hasAuthorship W2018446429A5024761796 @default.
- W2018446429 hasAuthorship W2018446429A5030261371 @default.
- W2018446429 hasAuthorship W2018446429A5072111063 @default.
- W2018446429 hasAuthorship W2018446429A5088629560 @default.
- W2018446429 hasBestOaLocation W20184464291 @default.
- W2018446429 hasConcept C104317684 @default.
- W2018446429 hasConcept C11960822 @default.
- W2018446429 hasConcept C152624196 @default.
- W2018446429 hasConcept C158617107 @default.
- W2018446429 hasConcept C170493617 @default.
- W2018446429 hasConcept C178790620 @default.
- W2018446429 hasConcept C184235292 @default.
- W2018446429 hasConcept C185592680 @default.
- W2018446429 hasConcept C18699975 @default.
- W2018446429 hasConcept C201571599 @default.
- W2018446429 hasConcept C2775880066 @default.
- W2018446429 hasConcept C2776414213 @default.
- W2018446429 hasConcept C2777313579 @default.
- W2018446429 hasConcept C2777427919 @default.
- W2018446429 hasConcept C28406088 @default.
- W2018446429 hasConcept C519063684 @default.
- W2018446429 hasConcept C53345823 @default.
- W2018446429 hasConcept C55493867 @default.
- W2018446429 hasConcept C86803240 @default.
- W2018446429 hasConcept C95444343 @default.
- W2018446429 hasConceptScore W2018446429C104317684 @default.
- W2018446429 hasConceptScore W2018446429C11960822 @default.
- W2018446429 hasConceptScore W2018446429C152624196 @default.
- W2018446429 hasConceptScore W2018446429C158617107 @default.
- W2018446429 hasConceptScore W2018446429C170493617 @default.
- W2018446429 hasConceptScore W2018446429C178790620 @default.
- W2018446429 hasConceptScore W2018446429C184235292 @default.
- W2018446429 hasConceptScore W2018446429C185592680 @default.
- W2018446429 hasConceptScore W2018446429C18699975 @default.
- W2018446429 hasConceptScore W2018446429C201571599 @default.
- W2018446429 hasConceptScore W2018446429C2775880066 @default.
- W2018446429 hasConceptScore W2018446429C2776414213 @default.
- W2018446429 hasConceptScore W2018446429C2777313579 @default.
- W2018446429 hasConceptScore W2018446429C2777427919 @default.
- W2018446429 hasConceptScore W2018446429C28406088 @default.
- W2018446429 hasConceptScore W2018446429C519063684 @default.
- W2018446429 hasConceptScore W2018446429C53345823 @default.
- W2018446429 hasConceptScore W2018446429C55493867 @default.
- W2018446429 hasConceptScore W2018446429C86803240 @default.
- W2018446429 hasConceptScore W2018446429C95444343 @default.
- W2018446429 hasLocation W20184464291 @default.
- W2018446429 hasOpenAccess W2018446429 @default.
- W2018446429 hasPrimaryLocation W20184464291 @default.
- W2018446429 hasRelatedWork W1834569838 @default.
- W2018446429 hasRelatedWork W1965415643 @default.
- W2018446429 hasRelatedWork W1976746355 @default.
- W2018446429 hasRelatedWork W1981491992 @default.
- W2018446429 hasRelatedWork W1995179004 @default.
- W2018446429 hasRelatedWork W1998828489 @default.
- W2018446429 hasRelatedWork W2010754860 @default.
- W2018446429 hasRelatedWork W2022021861 @default.
- W2018446429 hasRelatedWork W2035786682 @default.
- W2018446429 hasRelatedWork W2061974563 @default.
- W2018446429 hasRelatedWork W2064693834 @default.
- W2018446429 hasRelatedWork W2078842725 @default.
- W2018446429 hasRelatedWork W2118559747 @default.
- W2018446429 hasRelatedWork W2124353324 @default.
- W2018446429 hasRelatedWork W2126293964 @default.
- W2018446429 hasRelatedWork W2127265455 @default.
- W2018446429 hasRelatedWork W2143843444 @default.
- W2018446429 hasRelatedWork W2148049759 @default.
- W2018446429 hasRelatedWork W2194279174 @default.
- W2018446429 hasRelatedWork W2437576072 @default.
- W2018446429 isParatext "false" @default.
- W2018446429 isRetracted "false" @default.
- W2018446429 magId "2018446429" @default.
- W2018446429 workType "article" @default.