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• W2018448066 abstract "Limb regeneration requires the coordination of multiple stem cell populations to recapitulate the process of tissue formation. Therefore, bone marrow (BM) -derived cell regulation of skeletal muscle regeneration was examined in mice lacking the CC chemokine receptor 2 (CCR2). Myofiber size, numbers of myogenic progenitor cells (MPCs), and recruitment of BM-derived cells and macrophages were assessed after cardiotoxin-induced injury of chimeric mice produced by transplanting BM from wild-type (WT) or CCR2(-/-) mice into irradiated WT or CCR2(-/-) host mice. Regardless of the host genotype, muscle regeneration and recruitment of BM-derived cells and macrophages were similar in mice replenished with WT BM, whereas BM-derived cells and macrophage accumulation were decreased and muscle regeneration was impaired in all animals receiving CCR2(-/-) BM. Furthermore, numbers of MPCs (CD34(+)/Sca-1(-)/CD45(-) cells) were significantly increased in mice receiving CCR2(-/-) BM despite the decreased size of regenerated myofibers. Thus, the expression of CCR2 on BM-derived cells regulated macrophage recruitment into injured muscle, numbers of MPC, and the extent of regenerated myofiber size, all of which were independent of CCR2 expression on host-derived cells. Future studies in regenerative medicine must include consideration of the role of BM-derived cells, possibly macrophages, in CCR2-dependent events that regulate effective skeletal muscle regeneration." @default.
• W2018448066 created "2016-06-24" @default.
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• W2018448066 date "2008-09-30" @default.
• W2018448066 modified "2023-09-24" @default.
• W2018448066 title "Bone marrow‐derived cell regulation of skeletal muscle regeneration" @default.
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• W2018448066 doi "https://doi.org/10.1096/fj.07-095901" @default.
• W2018448066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2630778" @default.
• W2018448066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18827026" @default.
• W2018448066 hasPublicationYear "2008" @default.
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