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- W2018449488 abstract "Peripheral CD4 T‐cell depletion has been observed in human immunodeficiency virus (HIV)‐negative patients with pulmonary tuberculosis (TB). To investigate more accurately this alteration, we studied peripheral blood CD45RA + and CD29 high CD4 subsets in 79 TB patients with (HIV + TB + ) or without (HIV − TB + ) HIV infection, 85 HIV‐infected patients without TB (HIV + TB − ), and 43 healthy controls, all living in West Africa. The high proportion of CD4 + CD29 high T cells observed in controls was dramatically decreased in CDC‐A stage HIV + TB − patients. CD45RA + CD4 + T cells were depleted during the CDC‐B stage. Both the percentage and the absolute count of CD29 high CD4 + T cells were decreased in HIV − TB + and HIV + TB + patients versus controls, but CD45RA + CD4 + T cells were not decreased in TB patients without HIV‐infection. Although distinct alterations in the CD4 + T‐cell homeostasis are involved in TB‐ versus HIV‐infected subjects, our data suggest that the CD29 + CD4 + T‐cell depletion observed during the early HIV disease contributes to the risk of active TB, by reducing the pool of T cells able to relocalize to the sites of the M. tuberculosis multiplication." @default.
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- W2018449488 date "2001-01-01" @default.
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- W2018449488 title "Alteration in CD29<sup>high</sup>CD4<sup>+</sup>Lymphocyte Subset is a Common Feature of Early HIV Disease and of Active Tuberculosis" @default.
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- W2018449488 doi "https://doi.org/10.1046/j.1365-3083.2001.00832.x" @default.
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