FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018460745> ?p ?o ?g. }

• W2018460745 endingPage "10551" @default.
• W2018460745 startingPage "10544" @default.
• W2018460745 abstract "A major link between inflammation and cancer is provided by NF-kappaB transcription factors. Ikkbeta(Deltahep) mice, which specifically lack IkappaB kinase beta (IKKbeta), an activator of NF-kappaB, in hepatocytes, are unable to activate NF-kappaB in response to proinflammatory stimuli, such as TNF-alpha. Surprisingly, Ikkbeta(Deltahep) mice are hypersusceptible to diethylnitrosamine (DEN)-induced hepatocarcinogenesis. Because defective NF-kappaB activation promotes sustained c-Jun N-terminal kinase (JNK) activation in cells exposed to TNF-alpha, whose expression is induced by DEN, and JNK activity is required for normal hepatocyte proliferation, we examined whether increased susceptibility to DEN-induced hepatocarcinogenesis in Ikkbeta(Deltahep) mice requires JNK activation. Hepatocytes express both JNK1 and JNK2, but previous studies indicate that JNK1 is more important for hepatocyte proliferation. We therefore investigated this hypothesis using mice homozygous for a JNK1 deficiency either in wild-type or Ikkbeta(Deltahep) backgrounds. In both cases, mice lacking JNK1 were much less susceptible to DEN-induced hepatocarcinogenesis. This impaired tumorigenesis correlated with decreased expression of cyclin D and vascular endothelial growth factor, diminished cell proliferation, and reduced tumor neovascularization. Whereas hepatocyte-specific deletion of IKKbeta augmented DEN-induced hepatocyte death and cytokine-driven compensatory proliferation, disruption of JNK1 abrogated this response. In addition to underscoring the importance of JNK1-mediated hepatocyte death and compensatory proliferation, these results strongly suggest that the control of tissue renewal through the IKK and JNK pathways plays a key role in liver carcinogenesis." @default.
• W2018460745 created "2016-06-24" @default.
• W2018460745 creator A5005124549 @default.
• W2018460745 creator A5056315342 @default.
• W2018460745 creator A5075001959 @default.
• W2018460745 creator A5085819007 @default.
• W2018460745 date "2006-07-11" @default.
• W2018460745 modified "2023-10-05" @default.
• W2018460745 title "Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation" @default.
• W2018460745 cites W1494354791 @default.
• W2018460745 cites W1523142723 @default.
• W2018460745 cites W1536999296 @default.
• W2018460745 cites W1537712767 @default.
• W2018460745 cites W1553712313 @default.
• W2018460745 cites W1563090311 @default.
• W2018460745 cites W1929153087 @default.
• W2018460745 cites W1945598588 @default.
• W2018460745 cites W1955049958 @default.
• W2018460745 cites W1976382352 @default.
• W2018460745 cites W1980138415 @default.
• W2018460745 cites W1986427635 @default.
• W2018460745 cites W1988924112 @default.
• W2018460745 cites W1990752073 @default.
• W2018460745 cites W1992970966 @default.
• W2018460745 cites W1994219871 @default.
• W2018460745 cites W2004141049 @default.
• W2018460745 cites W2016961672 @default.
• W2018460745 cites W2024131284 @default.
• W2018460745 cites W2027962951 @default.
• W2018460745 cites W2031073046 @default.
• W2018460745 cites W2040532363 @default.
• W2018460745 cites W2042260090 @default.
• W2018460745 cites W2043493252 @default.
• W2018460745 cites W2046056065 @default.
• W2018460745 cites W2046440869 @default.
• W2018460745 cites W2050516456 @default.
• W2018460745 cites W2057942179 @default.
• W2018460745 cites W2059194853 @default.
• W2018460745 cites W2075964433 @default.
• W2018460745 cites W2076515532 @default.
• W2018460745 cites W2076987462 @default.
• W2018460745 cites W2077880395 @default.
• W2018460745 cites W2089082314 @default.
• W2018460745 cites W2093005090 @default.
• W2018460745 cites W2097672870 @default.
• W2018460745 cites W2103637700 @default.
• W2018460745 cites W2105846857 @default.
• W2018460745 cites W2110879481 @default.
• W2018460745 cites W2114111268 @default.
• W2018460745 cites W2117282734 @default.
• W2018460745 cites W2124076790 @default.
• W2018460745 cites W2127649862 @default.
• W2018460745 cites W2130550745 @default.
• W2018460745 cites W2133984207 @default.
• W2018460745 cites W2137257146 @default.
• W2018460745 cites W2154823420 @default.
• W2018460745 cites W2165523086 @default.
• W2018460745 cites W2169385554 @default.
• W2018460745 cites W2170915150 @default.
• W2018460745 cites W2325720000 @default.
• W2018460745 cites W2407956211 @default.
• W2018460745 cites W2417104161 @default.
• W2018460745 cites W2557080683 @default.
• W2018460745 cites W4237329722 @default.
• W2018460745 doi "https://doi.org/10.1073/pnas.0603499103" @default.
• W2018460745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1502270" @default.
• W2018460745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16807293" @default.
• W2018460745 hasPublicationYear "2006" @default.
• W2018460745 type Work @default.
• W2018460745 sameAs 2018460745 @default.
• W2018460745 citedByCount "380" @default.
• W2018460745 countsByYear W20184607452012 @default.
• W2018460745 countsByYear W20184607452013 @default.
• W2018460745 countsByYear W20184607452014 @default.
• W2018460745 countsByYear W20184607452015 @default.
• W2018460745 countsByYear W20184607452016 @default.
• W2018460745 countsByYear W20184607452017 @default.
• W2018460745 countsByYear W20184607452018 @default.
• W2018460745 countsByYear W20184607452019 @default.
• W2018460745 countsByYear W20184607452020 @default.
• W2018460745 countsByYear W20184607452021 @default.
• W2018460745 countsByYear W20184607452022 @default.
• W2018460745 countsByYear W20184607452023 @default.
• W2018460745 crossrefType "journal-article" @default.
• W2018460745 hasAuthorship W2018460745A5005124549 @default.
• W2018460745 hasAuthorship W2018460745A5056315342 @default.
• W2018460745 hasAuthorship W2018460745A5075001959 @default.
• W2018460745 hasAuthorship W2018460745A5085819007 @default.
• W2018460745 hasBestOaLocation W20184607451 @default.
• W2018460745 hasConcept C100175707 @default.
• W2018460745 hasConcept C104317684 @default.
• W2018460745 hasConcept C121608353 @default.
• W2018460745 hasConcept C126322002 @default.
• W2018460745 hasConcept C134018914 @default.
• W2018460745 hasConcept C164027704 @default.
• W2018460745 hasConcept C170493617 @default.
• W2018460745 hasConcept C184235292 @default.
• W2018460745 hasConcept C202751555 @default.

• next