FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018462357> ?p ?o ?g. }

• W2018462357 endingPage "10005" @default.
• W2018462357 startingPage "9999" @default.
• W2018462357 abstract "Abstract The underlying primary damage to the seminiferous epithelium caused by chemotherapeutic regimens at childhood is largely unknown. The present investigation was designed to identify acute cytotoxic events in the testis caused by a single dose of doxorubicin. Male rats at 6, 16, and 24 days of age were injected with doxorubicin (3 mg/kg, i.p.) or vehicle (saline) alone and 24 and 48 hours later, the germ cell types and apoptotic cells in the seminiferous epithelium were examined. As indicated by microscopy and terminal deoxyribonucleotidyl transferase–mediated dUTP nick end labeling staining, an 8-fold increase in the number of apoptotic germ cells in the testes of 6-day-old rats was observed 48 hours after doxorubicin treatment. Spermatogonia migrating to the basement membrane were the primary cell type undergoing this induced apoptosis. A single dose of amifostine (200 mg/kg) administered i.p. 15 minutes before injection of doxorubicin provided no protection against this enhanced apoptosis. Under the same conditions, testicular levels of p53 and activated caspase 8 were elevated, whereas the level of murine double minute-2 was lowered. In contrast, doxorubicin treatment did not result in any significant change in the physiologic, stage-specific germ cell apoptosis occurring in the testes of 16- and 24-day-old rats. These observations suggest that the initiation phase of spermatogenesis is highly sensitive to doxorubicin-induced apoptosis. Gonocytes and early spermatogonia are the cell types that are vulnerable to this p53-trigged apoptosis, which results in a decrease in the size of the pool of germ-line stem cells. Amifostine fails to protect the germ cells against this cytotoxic insult." @default.
• W2018462357 created "2016-06-24" @default.
• W2018462357 creator A5012866554 @default.
• W2018462357 creator A5015673000 @default.
• W2018462357 creator A5042125812 @default.
• W2018462357 creator A5046023727 @default.
• W2018462357 creator A5059535403 @default.
• W2018462357 creator A5062996235 @default.
• W2018462357 creator A5076309463 @default.
• W2018462357 date "2005-11-01" @default.
• W2018462357 modified "2023-10-10" @default.
• W2018462357 title "Doxorubicin Induces Apoptosis in Germ Line Stem Cells in the Immature Rat Testis and Amifostine Cannot Protect against This Cytotoxicity" @default.
• W2018462357 cites W1964597297 @default.
• W2018462357 cites W1965706580 @default.
• W2018462357 cites W1969985548 @default.
• W2018462357 cites W1970611407 @default.
• W2018462357 cites W1984055292 @default.
• W2018462357 cites W1984372372 @default.
• W2018462357 cites W1996501957 @default.
• W2018462357 cites W2014342794 @default.
• W2018462357 cites W2016552156 @default.
• W2018462357 cites W2019886665 @default.
• W2018462357 cites W2021066535 @default.
• W2018462357 cites W2024003914 @default.
• W2018462357 cites W2027360500 @default.
• W2018462357 cites W2029668011 @default.
• W2018462357 cites W2032725365 @default.
• W2018462357 cites W2052867110 @default.
• W2018462357 cites W2058507495 @default.
• W2018462357 cites W2060217553 @default.
• W2018462357 cites W2065914616 @default.
• W2018462357 cites W2071926776 @default.
• W2018462357 cites W2074212982 @default.
• W2018462357 cites W2077937196 @default.
• W2018462357 cites W2080125477 @default.
• W2018462357 cites W2140698430 @default.
• W2018462357 cites W2143252429 @default.
• W2018462357 cites W2149859911 @default.
• W2018462357 cites W2885547015 @default.
• W2018462357 doi "https://doi.org/10.1158/0008-5472.can-05-2004" @default.
• W2018462357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16267025" @default.
• W2018462357 hasPublicationYear "2005" @default.
• W2018462357 type Work @default.
• W2018462357 sameAs 2018462357 @default.
• W2018462357 citedByCount "116" @default.
• W2018462357 countsByYear W20184623572012 @default.
• W2018462357 countsByYear W20184623572013 @default.
• W2018462357 countsByYear W20184623572014 @default.
• W2018462357 countsByYear W20184623572015 @default.
• W2018462357 countsByYear W20184623572017 @default.
• W2018462357 countsByYear W20184623572018 @default.
• W2018462357 countsByYear W20184623572019 @default.
• W2018462357 countsByYear W20184623572020 @default.
• W2018462357 countsByYear W20184623572021 @default.
• W2018462357 countsByYear W20184623572022 @default.
• W2018462357 countsByYear W20184623572023 @default.
• W2018462357 crossrefType "journal-article" @default.
• W2018462357 hasAuthorship W2018462357A5012866554 @default.
• W2018462357 hasAuthorship W2018462357A5015673000 @default.
• W2018462357 hasAuthorship W2018462357A5042125812 @default.
• W2018462357 hasAuthorship W2018462357A5046023727 @default.
• W2018462357 hasAuthorship W2018462357A5059535403 @default.
• W2018462357 hasAuthorship W2018462357A5062996235 @default.
• W2018462357 hasAuthorship W2018462357A5076309463 @default.
• W2018462357 hasBestOaLocation W20184623571 @default.
• W2018462357 hasConcept C104317684 @default.
• W2018462357 hasConcept C123765429 @default.
• W2018462357 hasConcept C126322002 @default.
• W2018462357 hasConcept C134018914 @default.
• W2018462357 hasConcept C16685009 @default.
• W2018462357 hasConcept C190283241 @default.
• W2018462357 hasConcept C2776694085 @default.
• W2018462357 hasConcept C2779122487 @default.
• W2018462357 hasConcept C2779387952 @default.
• W2018462357 hasConcept C2781068068 @default.
• W2018462357 hasConcept C2781303535 @default.
• W2018462357 hasConcept C28328180 @default.
• W2018462357 hasConcept C502942594 @default.
• W2018462357 hasConcept C55493867 @default.
• W2018462357 hasConcept C71924100 @default.
• W2018462357 hasConcept C84298646 @default.
• W2018462357 hasConcept C86803240 @default.
• W2018462357 hasConcept C95444343 @default.
• W2018462357 hasConceptScore W2018462357C104317684 @default.
• W2018462357 hasConceptScore W2018462357C123765429 @default.
• W2018462357 hasConceptScore W2018462357C126322002 @default.
• W2018462357 hasConceptScore W2018462357C134018914 @default.
• W2018462357 hasConceptScore W2018462357C16685009 @default.
• W2018462357 hasConceptScore W2018462357C190283241 @default.
• W2018462357 hasConceptScore W2018462357C2776694085 @default.
• W2018462357 hasConceptScore W2018462357C2779122487 @default.
• W2018462357 hasConceptScore W2018462357C2779387952 @default.
• W2018462357 hasConceptScore W2018462357C2781068068 @default.
• W2018462357 hasConceptScore W2018462357C2781303535 @default.
• W2018462357 hasConceptScore W2018462357C28328180 @default.
• W2018462357 hasConceptScore W2018462357C502942594 @default.
• W2018462357 hasConceptScore W2018462357C55493867 @default.
• W2018462357 hasConceptScore W2018462357C71924100 @default.

• next