FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018467567> ?p ?o ?g. }

• W2018467567 endingPage "223" @default.
• W2018467567 startingPage "218" @default.
• W2018467567 abstract "Latent infection of human ganglia with Varicella-Zoster virus (VZV) is characterized by a highly restricted pattern of viral gene expression. To enhance understanding of this process we used in situ hybridization (ISH) in a rat model of VZV latency to examine expression of RNA corresponding to eight different VZV genes in rat dorsal root ganglia (DRG) at various times after footpad inoculation with wild-type VZV. PCR in situ amplification was also used to determine the cell specificity of latent VZV DNA. It was found that the pattern of viral gene expression at 1 week after infection was different from that observed at the later times of 1 and 18 months after infection. Whereas multiple genes were expressed at 1 week after infection, gene expression was restricted at the later time points when latency had been established. At the later time points after infection the RNA transcripts expressed most frequently were those for VZV genes 21, 62, and 63. Gene 63 was expressed more than any other gene studied. While VZV DNA was detected almost exclusively in 5-10% of neurons, VZV RNA was detected in both neurons and nonneuronal cells at an approximate ratio of 3:1. A newly described monoclonal antibody to VZV gene 63-encoded protein was used to detect this protein in neuronal nuclei and cytoplasm in almost half of the DRG studied. These results demonstrate that (1) this rat model of latency has close similarities in terms of viral gene expression to human VZV latency which makes it a useful tool for studying this process and its experimental modulation and (2) expression of VZV gene 63 appears to be the single most consistent feature of VZV latency." @default.
• W2018467567 created "2016-06-24" @default.
• W2018467567 creator A5002280659 @default.
• W2018467567 creator A5009720122 @default.
• W2018467567 creator A5029972124 @default.
• W2018467567 creator A5049569148 @default.
• W2018467567 date "2001-10-01" @default.
• W2018467567 modified "2023-09-28" @default.
• W2018467567 title "Varicella-Zoster Virus Gene Expression in Latently Infected Rat Dorsal Root Ganglia" @default.
• W2018467567 cites W1588727912 @default.
• W2018467567 cites W1964827334 @default.
• W2018467567 cites W1984267881 @default.
• W2018467567 cites W1997910335 @default.
• W2018467567 cites W2003437843 @default.
• W2018467567 cites W2028287752 @default.
• W2018467567 cites W2037451072 @default.
• W2018467567 cites W2053624063 @default.
• W2018467567 cites W2059658963 @default.
• W2018467567 cites W2065879323 @default.
• W2018467567 cites W2068474178 @default.
• W2018467567 cites W2109834166 @default.
• W2018467567 cites W2127810556 @default.
• W2018467567 cites W2128563606 @default.
• W2018467567 cites W2137726006 @default.
• W2018467567 cites W2167892454 @default.
• W2018467567 cites W2321123402 @default.
• W2018467567 doi "https://doi.org/10.1006/viro.2001.1173" @default.
• W2018467567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11689044" @default.
• W2018467567 hasPublicationYear "2001" @default.
• W2018467567 type Work @default.
• W2018467567 sameAs 2018467567 @default.
• W2018467567 citedByCount "97" @default.
• W2018467567 countsByYear W20184675672012 @default.
• W2018467567 countsByYear W20184675672013 @default.
• W2018467567 countsByYear W20184675672014 @default.
• W2018467567 countsByYear W20184675672015 @default.
• W2018467567 countsByYear W20184675672016 @default.
• W2018467567 countsByYear W20184675672017 @default.
• W2018467567 countsByYear W20184675672018 @default.
• W2018467567 countsByYear W20184675672019 @default.
• W2018467567 countsByYear W20184675672020 @default.
• W2018467567 countsByYear W20184675672021 @default.
• W2018467567 countsByYear W20184675672022 @default.
• W2018467567 countsByYear W20184675672023 @default.
• W2018467567 crossrefType "journal-article" @default.
• W2018467567 hasAuthorship W2018467567A5002280659 @default.
• W2018467567 hasAuthorship W2018467567A5009720122 @default.
• W2018467567 hasAuthorship W2018467567A5029972124 @default.
• W2018467567 hasAuthorship W2018467567A5049569148 @default.
• W2018467567 hasBestOaLocation W20184675671 @default.
• W2018467567 hasConcept C104317684 @default.
• W2018467567 hasConcept C140704245 @default.
• W2018467567 hasConcept C150194340 @default.
• W2018467567 hasConcept C153911025 @default.
• W2018467567 hasConcept C159047783 @default.
• W2018467567 hasConcept C2522874641 @default.
• W2018467567 hasConcept C2776159415 @default.
• W2018467567 hasConcept C2776409557 @default.
• W2018467567 hasConcept C2778852064 @default.
• W2018467567 hasConcept C2780727368 @default.
• W2018467567 hasConcept C54355233 @default.
• W2018467567 hasConcept C67705224 @default.
• W2018467567 hasConcept C81439078 @default.
• W2018467567 hasConcept C86803240 @default.
• W2018467567 hasConceptScore W2018467567C104317684 @default.
• W2018467567 hasConceptScore W2018467567C140704245 @default.
• W2018467567 hasConceptScore W2018467567C150194340 @default.
• W2018467567 hasConceptScore W2018467567C153911025 @default.
• W2018467567 hasConceptScore W2018467567C159047783 @default.
• W2018467567 hasConceptScore W2018467567C2522874641 @default.
• W2018467567 hasConceptScore W2018467567C2776159415 @default.
• W2018467567 hasConceptScore W2018467567C2776409557 @default.
• W2018467567 hasConceptScore W2018467567C2778852064 @default.
• W2018467567 hasConceptScore W2018467567C2780727368 @default.
• W2018467567 hasConceptScore W2018467567C54355233 @default.
• W2018467567 hasConceptScore W2018467567C67705224 @default.
• W2018467567 hasConceptScore W2018467567C81439078 @default.
• W2018467567 hasConceptScore W2018467567C86803240 @default.
• W2018467567 hasIssue "2" @default.
• W2018467567 hasLocation W20184675671 @default.
• W2018467567 hasLocation W20184675672 @default.
• W2018467567 hasLocation W20184675673 @default.
• W2018467567 hasOpenAccess W2018467567 @default.
• W2018467567 hasPrimaryLocation W20184675671 @default.
• W2018467567 hasRelatedWork W1846954693 @default.
• W2018467567 hasRelatedWork W2004297244 @default.
• W2018467567 hasRelatedWork W2005460711 @default.
• W2018467567 hasRelatedWork W2018467567 @default.
• W2018467567 hasRelatedWork W2038801503 @default.
• W2018467567 hasRelatedWork W2122893310 @default.
• W2018467567 hasRelatedWork W2139021209 @default.
• W2018467567 hasRelatedWork W2153434009 @default.
• W2018467567 hasRelatedWork W2412545951 @default.
• W2018467567 hasRelatedWork W1428214394 @default.
• W2018467567 hasVolume "289" @default.
• W2018467567 isParatext "false" @default.
• W2018467567 isRetracted "false" @default.
• W2018467567 magId "2018467567" @default.

• next