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• W2018468627 abstract "Cyclodextrins (CDs) are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. CD molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, CDs have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. CDs are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current CD-based therapeutics is described and possible future applications are discussed. CD-containing polymers are reviewed and their use in drug delivery is presented. Of specific interest is the use of CD-containing polymers to provide unique capabilities for the delivery of nucleic acids. Studies in both humans and animals have shown that CDs can be used to improve drug delivery from almost any type of drug formulation. Currently, there are approximately 30 different pharmaceutical products worldwide containing drug/CD complexes in the market." @default.
• W2018468627 created "2016-06-24" @default.
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• W2018468627 creator A5067007215 @default.
• W2018468627 date "2010-01-01" @default.
• W2018468627 modified "2023-10-16" @default.
• W2018468627 title "Cyclodextrins in delivery systems: Applications" @default.
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• W2018468627 doi "https://doi.org/10.4103/0975-7406.67003" @default.
• W2018468627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3147107" @default.
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