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• W2018481012 abstract "Functional neuroimaging techniques have allowed for investigations into the mechanisms of age-related deterioration in motor control. This study used functional Magnetic Resonance Imaging (fMRI) to investigate age related differences in the control of grip force magnitude. Using an event-related design, fMRI scans were completed on 13 older adults, and 13 gender matched younger adults, while using their dominant hand to squeeze a rubber bulb for 4 s at 10%, 40% or 70% of their maximum voluntary contraction. Both groups were able to match the relative force targets, however the older adults produced significantly lower levels of absolute force. fMRI analysis consisted of a 1) region of interest (ROI) approach to detect differences in selected motor areas within brain and 2) a voxel-wise whole brain comparison to find areas of differential activation that were not defined a priori between the older and younger group. The ROI analysis revealed that despite producing lower levels of absolute force, the older adults showed higher levels of activity predominantly in subcortical structures (putamen, thalamus and cerebellum) when compared to the younger group. The older adults also showed higher levels of activity in the ipsilateral ventral premotor cortex. A total of 19 of the 22 ROIs analyzed showed a significant main effect of the required force-level. In the majority of the ROIs that showed a significant force effect there were no significant differences in the magnitude of the blood-oxygen-level-dependent (BOLD) signal between the 10% and 40% conditions but a significantly higher BOLD signal in the 70% condition, suggesting that the modulation of brain activation with grip force may not be controlled in a linear fashion. It was also found that the older adult group demonstrate higher levels of activation in 7 areas during a force production task at higher force levels using a voxel-wise analysis. The 7 clusters that showed significant differences tended to be areas that are involved in visual–spatial and executive processing. The results of this study revealed that older adults require significantly higher activation of several areas to perform the same motor task as younger adults. Higher magnitudes of the BOLD signal in older adults may represent a compensatory pattern to counter age related deterioration in motor control systems." @default.
• W2018481012 created "2016-06-24" @default.
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• W2018481012 date "2011-06-01" @default.
• W2018481012 modified "2023-10-18" @default.
• W2018481012 title "Aging effects on the control of grip force magnitude: An fMRI study" @default.
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• W2018481012 doi "https://doi.org/10.1016/j.exger.2011.01.004" @default.
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