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- W2018482512 abstract "We have determined the percentage of CD5+ B lymphocytes in the peripheral blood of cancer patients and healthy controls, using antibodies directed at the CD5 and CD19 (pan-B) markers. The frequencies of CD5+ B cells, expressed as a percentage of total B cells, ranged from 14.3 to 57.5% in the controls and from 14.8 to 82.8% in the patient population. One-third of the cancer patients had frequencies greater than 2 s.d. above the mean of the control population. The CD5+ B cell fraction expressed as a percentage of total lymphocytes was also significantly elevated in this group of cancer patients. These results suggest that the CD5+ B cell compartment may be affected by the malignant process or by the therapy modality employed. The plasma levels of several naturally occurring autoantibodies, the products of the CD5+ B cells, were also assessed in cancer patients and controls. No significant differences were observed when reactivity to several autoantigens was measured. These included nuclear components and phospholipids." @default.
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- W2018482512 date "2008-06-28" @default.
- W2018482512 modified "2023-09-26" @default.
- W2018482512 title "CD5+ B cells and naturally occurring autoantibodies in cancer patients" @default.
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- W2018482512 doi "https://doi.org/10.1111/j.1365-2249.1991.tb05742.x" @default.
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