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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018483399> ?p ?o ?g. }

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• W2018483399 abstract "Glial-cell-line-derived neurotrophic factor (GDNF) acts as a potent survival factor for many neuronal populations, including retinal ganglion cells (RGC), indicating a potential therapeutic role of GDNF for neurological disorders. To enhance the tissue distribution and applicability of the neurotrophin, we linked it to a protein transduction domain derived from the HIV TAT protein and tested it in a well-established model for traumatic injury in the CNS: After optic nerve axotomy, the number of surviving RGCs was significantly increased in mice injected with TAT-GDNF on days 0, 3, 7, and 10 after surgery compared with GDNF- or PBS-injected animals. Moreover, TAT-GDNF reduced the number of activated caspase-3-positive cells. These results show that the neuroprotective effect of substances like neurotrophins may be enhanced by linking them to a domain that has been shown to mediate efficient transduction across biological membranes." @default.
• W2018483399 created "2016-06-24" @default.
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• W2018483399 date "2004-01-01" @default.
• W2018483399 modified "2023-09-24" @default.
• W2018483399 title "The TAT Protein Transduction Domain Enhances the Neuroprotective Effect of Glial-Cell-Line-Derived Neurotrophic Factor after Optic Nerve Transection" @default.
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• W2018483399 doi "https://doi.org/10.1159/000076669" @default.
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