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- W2018490812 abstract "Mitochondria are known to actively regulate cell death with the final phenotype of demise being determined by the metabolic and energetic status of the cell. Mitochondrial membrane permeabilization (MMP) is a critical event in cell death, as it regulates the degree of mitochondrial dysfunction and the release of intermembrane proteins that function in the activation and assembly of caspases. In addition to the crucial role of proapoptotic members of the Bcl-2 family, the lipid composition of the mitochondrial membranes is increasingly recognized to modulate MMP and hence cell death. The unphysiological accumulation of cholesterol in mitochondrial membranes regulates their physical properties, facilitating or impairing MMP during Bax and death ligand-induced cell death depending on the level of mitochondrial GSH (mGSH), which in turn regulates the oxidation status of cardiolipin. Cholesterol-mediated mGSH depletion stimulates TNF-induced reactive oxygen species and subsequent cardiolipin peroxidation, which destabilizes the lipid bilayer and potentiates Bax-induced membrane permeabilization. These data suggest that the balance of mitochondrial cholesterol to peroxidized cardiolipin regulates mitochondrial membrane properties and permeabilization, emerging as a rheostat in cell death." @default.
- W2018490812 created "2016-06-24" @default.
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- W2018490812 date "2010-06-01" @default.
- W2018490812 modified "2023-10-18" @default.
- W2018490812 title "Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death" @default.
- W2018490812 cites W1480948328 @default.
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- W2018490812 cites W1836073275 @default.
- W2018490812 cites W1964483580 @default.
- W2018490812 cites W1970541648 @default.
- W2018490812 cites W1971186972 @default.
- W2018490812 cites W1976538401 @default.
- W2018490812 cites W1977258127 @default.
- W2018490812 cites W1980239153 @default.
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- W2018490812 cites W1989719889 @default.
- W2018490812 cites W1993256031 @default.
- W2018490812 cites W1993668532 @default.
- W2018490812 cites W1996271683 @default.
- W2018490812 cites W1998019353 @default.
- W2018490812 cites W2001382708 @default.
- W2018490812 cites W2010101404 @default.
- W2018490812 cites W2011614492 @default.
- W2018490812 cites W2013049918 @default.
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- W2018490812 doi "https://doi.org/10.1016/j.bbabio.2010.02.010" @default.
- W2018490812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2889134" @default.
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