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- W2018498082 abstract "Abstract Studies on the metabolism of [ 14 C]biphenyl and of 2-hydroxy and 4-hydroxybiphenyls confirm that preincubation of fresh hepatic microsomal preparations from rats or hamsters with chemical carcinogens such as safrole, benz[a]pyrene and 2-acetamidofluorene and a NADPH regenerating system produces an increase in the levels of 2-hydroxybiphenyl, through a specific increase in its formation from biphenyl. These data also support the validity of the fluorimetric assay method for monitoring this reaction. The addition of oestradiol or glutathione to the incubation mixture and the use of various preincubations and time periods with the carcinogens and NADPH prior to adding biphenyl indicate that production of an active metabolite of the carcinogens is probably a pre-requisite for the in vitro enhancement of biphenyl 2-hydroxylase to occur. The lack of effectiveness of EDTA in enhancing biphenyl 2-hydroxylase and the complete destruction of this enhancement by short-term storage of microsomal preparations at -20° suggests that the phenomenon is different from that of degranulation of the endoplasmic reticulum by carcinogens." @default.
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- W2018498082 title "Studies on the nature of the in vitro enhancement of biphenyl 2-hydroxylation provoked by some chemical carcinogens" @default.
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- W2018498082 doi "https://doi.org/10.1016/0006-2952(76)90102-7" @default.
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