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• W2018502083 abstract "Lung cancer is a highly aggressive neoplasm with 85% mortality. To identify new tumor-associated genes, we compared the expression profile of a primary metastasizing adenocarcinoma with normal airway epithelial cells. Two cDNA libraries of up- and downregulated genes were generated, comprising 253 and 299 clones, respectively. The sequence analysis revealed 205 different known genes and 314 cDNA fragments of unknown functions. Northern-blot analysis of 167 clones confirmed differential expression in 58%, and indicated a similar expression pattern in additional lung-cancer cell lines for selected clones, strengthening the value of this model for the identification of new candidate genes in lung carcinogenesis. Int. J. Cancer 86:512–517, 2000. © 2000 Wiley-Liss, Inc." @default.
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• W2018502083 date "2000-05-15" @default.
• W2018502083 modified "2023-10-16" @default.
• W2018502083 title "Gene expression profiling of advanced lung cancer" @default.
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• W2018502083 doi "https://doi.org/10.1002/(sici)1097-0215(20000515)86:4<512::aid-ijc11>3.0.co;2-6" @default.
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