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- W2018506593 abstract "Bacillus anthracis, a gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA+LF) provokes a subit death in animals, the edema toxin (PA+EF) induces edema. The edema and the lethal factors are internalised into the eukaryotic target cells via the protective antigen. EF and LF exert a calmoduline dependent adenylate cyclase and a metalloprotease activity respectively. Progress in the structure-function relationship of these three proteins, their regulation mechanisms and their roles in pathogenesis and immunoprotection will be exposed." @default.
- W2018506593 created "2016-06-24" @default.
- W2018506593 creator A5033718137 @default.
- W2018506593 creator A5049927151 @default.
- W2018506593 date "2001-11-01" @default.
- W2018506593 modified "2023-09-30" @default.
- W2018506593 title "Toxins of Bacillus anthracis" @default.
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- W2018506593 doi "https://doi.org/10.1016/s0041-0101(01)00161-1" @default.
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