FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018506866> ?p ?o ?g. }

• W2018506866 endingPage "711" @default.
• W2018506866 startingPage "703" @default.
• W2018506866 abstract "Leishmania infantum cytosolic tryparedoxin (LiTXN1) can be regarded as a potential candidate for drug targeting. This redox active molecule, which belongs to the thioredoxin superfamily, is one constituent of the hydroperoxide elimination cascade in L. infantum and may also be involved in other cellular processes such as DNA synthesis or host-parasite interaction. In order to validate LiTXN1 as a drug target we have employed a gene replacement strategy. We observed that substitution of both chromosomal LiTXN1 alleles was only possible upon parasite complementation with an episomal copy of the gene. Furthermore, contrary to control parasites carrying the empty vector, both the insect and the mammalian stages of L. infantum retained the episomal copy of LiTXN1 in the absence of drug pressure. These results confirm the essentiality of LiTXN1 throughout the life cycle of the parasite, namely in the disease-causing amastigote stage. In addition, the data obtained showed that disruption of one allele of this gene leads only to a 25% reduction in the expression of LiTXN1. Even though this does not affect promastigote growth and susceptibility to hydrogen peroxide, ex vivo infection assays suggest that wild-type levels of LiTXN1 are required for optimal L. infantum virulence." @default.
• W2018506866 created "2016-06-24" @default.
• W2018506866 creator A5019120119 @default.
• W2018506866 creator A5047405328 @default.
• W2018506866 creator A5052182647 @default.
• W2018506866 creator A5065974461 @default.
• W2018506866 creator A5090375759 @default.
• W2018506866 date "2009-05-01" @default.
• W2018506866 modified "2023-10-01" @default.
• W2018506866 title "The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival" @default.
• W2018506866 cites W1523732731 @default.
• W2018506866 cites W1548408196 @default.
• W2018506866 cites W1557004909 @default.
• W2018506866 cites W1567647424 @default.
• W2018506866 cites W1964828026 @default.
• W2018506866 cites W1970732978 @default.
• W2018506866 cites W1971992878 @default.
• W2018506866 cites W1973543110 @default.
• W2018506866 cites W1977849948 @default.
• W2018506866 cites W1983909677 @default.
• W2018506866 cites W1988565813 @default.
• W2018506866 cites W1992801869 @default.
• W2018506866 cites W1993349273 @default.
• W2018506866 cites W1995892898 @default.
• W2018506866 cites W2000925370 @default.
• W2018506866 cites W2006723796 @default.
• W2018506866 cites W2010313380 @default.
• W2018506866 cites W2017500476 @default.
• W2018506866 cites W2023356380 @default.
• W2018506866 cites W2023772678 @default.
• W2018506866 cites W2024373248 @default.
• W2018506866 cites W2028861264 @default.
• W2018506866 cites W2032028059 @default.
• W2018506866 cites W2035523275 @default.
• W2018506866 cites W2046144222 @default.
• W2018506866 cites W2046724951 @default.
• W2018506866 cites W2063077244 @default.
• W2018506866 cites W2074929773 @default.
• W2018506866 cites W2078143761 @default.
• W2018506866 cites W2081297467 @default.
• W2018506866 cites W2084505046 @default.
• W2018506866 cites W2086004805 @default.
• W2018506866 cites W2092234024 @default.
• W2018506866 cites W2103650142 @default.
• W2018506866 cites W2111017833 @default.
• W2018506866 cites W2114491796 @default.
• W2018506866 cites W2116251790 @default.
• W2018506866 cites W2120023357 @default.
• W2018506866 cites W2131476646 @default.
• W2018506866 cites W2132863919 @default.
• W2018506866 cites W2137225884 @default.
• W2018506866 cites W2148686101 @default.
• W2018506866 cites W2149704806 @default.
• W2018506866 cites W2152686523 @default.
• W2018506866 cites W2157504129 @default.
• W2018506866 cites W2167579457 @default.
• W2018506866 cites W4240455210 @default.
• W2018506866 doi "https://doi.org/10.1016/j.ijpara.2008.11.009" @default.
• W2018506866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19135056" @default.
• W2018506866 hasPublicationYear "2009" @default.
• W2018506866 type Work @default.
• W2018506866 sameAs 2018506866 @default.
• W2018506866 citedByCount "65" @default.
• W2018506866 countsByYear W20185068662012 @default.
• W2018506866 countsByYear W20185068662013 @default.
• W2018506866 countsByYear W20185068662014 @default.
• W2018506866 countsByYear W20185068662015 @default.
• W2018506866 countsByYear W20185068662016 @default.
• W2018506866 countsByYear W20185068662017 @default.
• W2018506866 countsByYear W20185068662018 @default.
• W2018506866 countsByYear W20185068662019 @default.
• W2018506866 countsByYear W20185068662020 @default.
• W2018506866 countsByYear W20185068662021 @default.
• W2018506866 countsByYear W20185068662022 @default.
• W2018506866 countsByYear W20185068662023 @default.
• W2018506866 crossrefType "journal-article" @default.
• W2018506866 hasAuthorship W2018506866A5019120119 @default.
• W2018506866 hasAuthorship W2018506866A5047405328 @default.
• W2018506866 hasAuthorship W2018506866A5052182647 @default.
• W2018506866 hasAuthorship W2018506866A5065974461 @default.
• W2018506866 hasAuthorship W2018506866A5090375759 @default.
• W2018506866 hasConcept C104317684 @default.
• W2018506866 hasConcept C127716648 @default.
• W2018506866 hasConcept C136764020 @default.
• W2018506866 hasConcept C188082640 @default.
• W2018506866 hasConcept C2776555147 @default.
• W2018506866 hasConcept C2778689377 @default.
• W2018506866 hasConcept C2781092759 @default.
• W2018506866 hasConcept C2781257258 @default.
• W2018506866 hasConcept C3623737 @default.
• W2018506866 hasConcept C41008148 @default.
• W2018506866 hasConcept C54355233 @default.
• W2018506866 hasConcept C71928629 @default.
• W2018506866 hasConcept C86803240 @default.
• W2018506866 hasConcept C95444343 @default.
• W2018506866 hasConcept C98319499 @default.
• W2018506866 hasConceptScore W2018506866C104317684 @default.
• W2018506866 hasConceptScore W2018506866C127716648 @default.

• next