Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018546369> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2018546369 endingPage "142" @default.
- W2018546369 startingPage "134" @default.
- W2018546369 abstract "The activation by rat liver microsomal systems in vitro of a naturally occurring and a synthetic furan-containing toxin, aflatoxin B1 and 2-(N-ethylcarbamoyloxymethyl)furan (CMF) has been examined. Both compounds are metabolised to form products which bind covalently to DNA and microsomal protein, Using a specially designed two-chamber diffusion apparatus it has been demonstrated that the active metabolite of CMF is able to bind covalently to DNA separated by a membrane barrier from the microsomal site of activation. In the case of aflatoxin B1 the DNA must be in physical contact with the microsomal system for the active metabolite of aflatoxin B1 to bind covalently. Differences between the activation of the two compounds have also been found with regard to their relative efficiencies in binding to DNA and also the effects of the nucleophile GSH. These results have suggested that if the molecular mechanisms of activation of the two compounds be similar, other factors, for example differences in lipid solubility, may play important roles in determining the relative biological activaties of the compounds. The results suggested that the subcellular site of activation of aflatoxin B1, unlike that of CMF, may need to be adjacent to the target DNA. It is proposed that this site might be the outer nuclear membrane. Alternatively a carrier molecular might exist for the activated aflatoxin B1 metabolite in vivo." @default.
- W2018546369 created "2016-06-24" @default.
- W2018546369 creator A5024761896 @default.
- W2018546369 creator A5046395044 @default.
- W2018546369 creator A5089997718 @default.
- W2018546369 date "1979-06-01" @default.
- W2018546369 modified "2023-09-27" @default.
- W2018546369 title "The microsomal activation of aflatoxin B1 and 2-(N-ethylcarbamoyloxymethyl)furan in vitro using a novel diffusion apparatus" @default.
- W2018546369 cites W1532212858 @default.
- W2018546369 cites W176167287 @default.
- W2018546369 cites W1775749144 @default.
- W2018546369 cites W1990504006 @default.
- W2018546369 cites W1994964977 @default.
- W2018546369 cites W2017838909 @default.
- W2018546369 cites W2031112211 @default.
- W2018546369 cites W2092727047 @default.
- W2018546369 cites W2119006735 @default.
- W2018546369 cites W2127361222 @default.
- W2018546369 cites W2335394071 @default.
- W2018546369 doi "https://doi.org/10.1016/0304-4165(79)90333-7" @default.
- W2018546369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36175" @default.
- W2018546369 hasPublicationYear "1979" @default.
- W2018546369 type Work @default.
- W2018546369 sameAs 2018546369 @default.
- W2018546369 citedByCount "9" @default.
- W2018546369 crossrefType "journal-article" @default.
- W2018546369 hasAuthorship W2018546369A5024761896 @default.
- W2018546369 hasAuthorship W2018546369A5046395044 @default.
- W2018546369 hasAuthorship W2018546369A5089997718 @default.
- W2018546369 hasConcept C178790620 @default.
- W2018546369 hasConcept C180577832 @default.
- W2018546369 hasConcept C185592680 @default.
- W2018546369 hasConcept C202751555 @default.
- W2018546369 hasConcept C2777477808 @default.
- W2018546369 hasConcept C2778659115 @default.
- W2018546369 hasConcept C31903555 @default.
- W2018546369 hasConcept C40758303 @default.
- W2018546369 hasConcept C41625074 @default.
- W2018546369 hasConcept C552990157 @default.
- W2018546369 hasConcept C55493867 @default.
- W2018546369 hasConcept C71240020 @default.
- W2018546369 hasConcept C84699730 @default.
- W2018546369 hasConcept C87644729 @default.
- W2018546369 hasConceptScore W2018546369C178790620 @default.
- W2018546369 hasConceptScore W2018546369C180577832 @default.
- W2018546369 hasConceptScore W2018546369C185592680 @default.
- W2018546369 hasConceptScore W2018546369C202751555 @default.
- W2018546369 hasConceptScore W2018546369C2777477808 @default.
- W2018546369 hasConceptScore W2018546369C2778659115 @default.
- W2018546369 hasConceptScore W2018546369C31903555 @default.
- W2018546369 hasConceptScore W2018546369C40758303 @default.
- W2018546369 hasConceptScore W2018546369C41625074 @default.
- W2018546369 hasConceptScore W2018546369C552990157 @default.
- W2018546369 hasConceptScore W2018546369C55493867 @default.
- W2018546369 hasConceptScore W2018546369C71240020 @default.
- W2018546369 hasConceptScore W2018546369C84699730 @default.
- W2018546369 hasConceptScore W2018546369C87644729 @default.
- W2018546369 hasIssue "1" @default.
- W2018546369 hasLocation W20185463691 @default.
- W2018546369 hasLocation W20185463692 @default.
- W2018546369 hasOpenAccess W2018546369 @default.
- W2018546369 hasPrimaryLocation W20185463691 @default.
- W2018546369 hasRelatedWork W1606449442 @default.
- W2018546369 hasRelatedWork W1952484212 @default.
- W2018546369 hasRelatedWork W1973983361 @default.
- W2018546369 hasRelatedWork W2004241245 @default.
- W2018546369 hasRelatedWork W2069092327 @default.
- W2018546369 hasRelatedWork W2086349594 @default.
- W2018546369 hasRelatedWork W2119006735 @default.
- W2018546369 hasRelatedWork W2232615845 @default.
- W2018546369 hasRelatedWork W2951437655 @default.
- W2018546369 hasRelatedWork W2740928196 @default.
- W2018546369 hasVolume "585" @default.
- W2018546369 isParatext "false" @default.
- W2018546369 isRetracted "false" @default.
- W2018546369 magId "2018546369" @default.
- W2018546369 workType "article" @default.