FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018550051> ?p ?o ?g. }

• W2018550051 endingPage "e000707" @default.
• W2018550051 startingPage "e000707" @default.
• W2018550051 abstract "Measles vaccines (MV) have sex-differential effects on mortality not explained by protection against measles infection.The authors examined whether whole-cell diphtheria-tetanus-pertussis (DTP) vaccine has sex-differential and non-specific effects.Following previous reviews and a new search, the effect of DTP on mortality up to the next vaccination was assessed in all studies where DTP was given after BCG or DTP was given after MV and there was prospective follow-up after ascertainment of vaccination status.High-mortality countries in Africa and Asia.The initial observation of negative effect of DTP generated six hypotheses, which were examined in all available studies and two randomised trials reducing the time of exposure to DTP.Consistency between studies.In the first study, DTP had negative effects on survival in contrast to the beneficial effects of BCG and MV. This pattern was repeated in the six other studies available. Second, the two 'natural experiments' found significantly higher mortality for DTP-vaccinated compared with DTP-unvaccinated children. Third, the female-male mortality ratio was increased after DTP in all nine studies; in contrast, the ratio was decreased after BCG and MV in all studies. Fourth, the increased female mortality associated with high-titre measles vaccine was found only among children who had received DTP after high-titre measles vaccine. Fifth, in six randomised trials of early MV, female but not male mortality was increased if DTP was likely to be given after MV. Sixth, the mortality rate declined markedly for girls but not for boys when DTP-vaccinated children received MV. The authors reduced exposure to DTP as most recent vaccination by administering a live vaccine (MV and BCG) shortly after DTP. Both trials reduced child mortality.These observations are incompatible with DTP merely protecting against the targeted diseases. With herd immunity to whooping cough, DTP is associated with higher mortality for girls. Randomised studies of DTP are warranted to measure the true impact on survival." @default.
• W2018550051 created "2016-06-24" @default.
• W2018550051 creator A5010289609 @default.
• W2018550051 creator A5028407518 @default.
• W2018550051 creator A5041412637 @default.
• W2018550051 creator A5044591266 @default.
• W2018550051 creator A5051012828 @default.
• W2018550051 creator A5063889710 @default.
• W2018550051 date "2012-01-01" @default.
• W2018550051 modified "2023-10-06" @default.
• W2018550051 title "Testing the hypothesis that diphtheria–tetanus–pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries" @default.
• W2018550051 cites W1529869158 @default.
• W2018550051 cites W1538835382 @default.
• W2018550051 cites W1568390176 @default.
• W2018550051 cites W1579435595 @default.
• W2018550051 cites W1580457945 @default.
• W2018550051 cites W1584448102 @default.
• W2018550051 cites W1585181678 @default.
• W2018550051 cites W1587247212 @default.
• W2018550051 cites W1588693256 @default.
• W2018550051 cites W1591521164 @default.
• W2018550051 cites W1767934134 @default.
• W2018550051 cites W1827485670 @default.
• W2018550051 cites W1898917753 @default.
• W2018550051 cites W1949149840 @default.
• W2018550051 cites W1951330162 @default.
• W2018550051 cites W1965918232 @default.
• W2018550051 cites W1965952695 @default.
• W2018550051 cites W1969900808 @default.
• W2018550051 cites W1971483088 @default.
• W2018550051 cites W1972142618 @default.
• W2018550051 cites W1975346646 @default.
• W2018550051 cites W1976048858 @default.
• W2018550051 cites W1982373948 @default.
• W2018550051 cites W1982662660 @default.
• W2018550051 cites W1985401260 @default.
• W2018550051 cites W1986852814 @default.
• W2018550051 cites W1994269712 @default.
• W2018550051 cites W1994917397 @default.
• W2018550051 cites W1998496301 @default.
• W2018550051 cites W1998723334 @default.
• W2018550051 cites W1999285710 @default.
• W2018550051 cites W2001361637 @default.
• W2018550051 cites W2002772970 @default.
• W2018550051 cites W2003619575 @default.
• W2018550051 cites W2008675520 @default.
• W2018550051 cites W2009203266 @default.
• W2018550051 cites W2014441977 @default.
• W2018550051 cites W2014480218 @default.
• W2018550051 cites W2016991302 @default.
• W2018550051 cites W2021032766 @default.
• W2018550051 cites W2022085440 @default.
• W2018550051 cites W2022575619 @default.
• W2018550051 cites W2023529655 @default.
• W2018550051 cites W2024107162 @default.
• W2018550051 cites W2028392153 @default.
• W2018550051 cites W2028419694 @default.
• W2018550051 cites W2029316680 @default.
• W2018550051 cites W2029750622 @default.
• W2018550051 cites W2029818410 @default.
• W2018550051 cites W2031164321 @default.
• W2018550051 cites W2031574847 @default.
• W2018550051 cites W2042919971 @default.
• W2018550051 cites W2048619988 @default.
• W2018550051 cites W2051679765 @default.
• W2018550051 cites W2054408198 @default.
• W2018550051 cites W2055147385 @default.
• W2018550051 cites W2056280406 @default.
• W2018550051 cites W2059033592 @default.
• W2018550051 cites W2060960388 @default.
• W2018550051 cites W2062219772 @default.
• W2018550051 cites W2065256315 @default.
• W2018550051 cites W2072155675 @default.
• W2018550051 cites W2073229622 @default.
• W2018550051 cites W2073995237 @default.
• W2018550051 cites W2075631654 @default.
• W2018550051 cites W2078613739 @default.
• W2018550051 cites W2083548270 @default.
• W2018550051 cites W2086343026 @default.
• W2018550051 cites W2091184787 @default.
• W2018550051 cites W2096215627 @default.
• W2018550051 cites W2098376804 @default.
• W2018550051 cites W2101008378 @default.
• W2018550051 cites W2101538150 @default.
• W2018550051 cites W2102527401 @default.
• W2018550051 cites W2103753861 @default.
• W2018550051 cites W2104727514 @default.
• W2018550051 cites W2105028850 @default.
• W2018550051 cites W2108709882 @default.
• W2018550051 cites W2110792754 @default.
• W2018550051 cites W2113342438 @default.
• W2018550051 cites W2116797415 @default.
• W2018550051 cites W2124947186 @default.
• W2018550051 cites W2129764321 @default.
• W2018550051 cites W2131779089 @default.
• W2018550051 cites W2134287833 @default.
• W2018550051 cites W2135115112 @default.
• W2018550051 cites W2139120583 @default.

• next