Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018551404> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2018551404 endingPage "144" @default.
- W2018551404 startingPage "133" @default.
- W2018551404 abstract "1. The absorption, distribution, metabolism and excretion of benoxaprofen, a novel anti-inflammatory compound, has been studied in the dog, mouse, rat, rabbit, rhesus monkey and man. 2. Benoxaprofen was well absorbed after oral administration of doses of 1 to 10 mg/kg in all six species. Only unchanged drug was detected in plasma. It was extensively bound to plasma proteins, the highest binding occurring in man (99.8%) and rhesus monkey (99.6%). 3. Species differences were observed in the plasma elimination half-life, the longest being in man (33 h). The rat and mouse also had high values (28 and 24 h respectively) whereas in the other species, values were less than 13 h. 4. After an oral dose of [14C]benoxaprofen (20 mg/kg) to female rats, tissue concn. was highest in liver, kidney, lungs, adrenals and ovaries. Tissue distribution in the pregnant rat was identical to the normal female. The compound was found in the foetus but at a concn. lower than in all maternal organs. 5. There was a marked species difference in the route of excretion. In man, rhesus monkey and rabbit, excretion in the urine was a major route, whilst biliary--faecal excretion was the only effective route in the rat and dog. 6. No major metabolic transformation of benoxaprofen was observed. Man and dog excreted the compound predominantly as the ester glucuronide whereas the rat, mouse, rabbit and rhesus monkey excreted a large proportion of the dose unchanged." @default.
- W2018551404 created "2016-06-24" @default.
- W2018551404 creator A5041576453 @default.
- W2018551404 creator A5052100986 @default.
- W2018551404 date "1978-01-01" @default.
- W2018551404 modified "2023-10-12" @default.
- W2018551404 title "Disposition and Metabolism of Benoxaprofen in Laboratory Animals and Man" @default.
- W2018551404 cites W1978463373 @default.
- W2018551404 cites W2019574047 @default.
- W2018551404 cites W2026032291 @default.
- W2018551404 cites W2026912546 @default.
- W2018551404 cites W2033113365 @default.
- W2018551404 cites W2094930319 @default.
- W2018551404 cites W2139699067 @default.
- W2018551404 cites W2413244612 @default.
- W2018551404 doi "https://doi.org/10.3109/00498257809060392" @default.
- W2018551404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/418580" @default.
- W2018551404 hasPublicationYear "1978" @default.
- W2018551404 type Work @default.
- W2018551404 sameAs 2018551404 @default.
- W2018551404 citedByCount "46" @default.
- W2018551404 countsByYear W20185514042012 @default.
- W2018551404 countsByYear W20185514042017 @default.
- W2018551404 crossrefType "journal-article" @default.
- W2018551404 hasAuthorship W2018551404A5041576453 @default.
- W2018551404 hasAuthorship W2018551404A5052100986 @default.
- W2018551404 hasConcept C10146269 @default.
- W2018551404 hasConcept C110121322 @default.
- W2018551404 hasConcept C112705442 @default.
- W2018551404 hasConcept C126322002 @default.
- W2018551404 hasConcept C134018914 @default.
- W2018551404 hasConcept C134306372 @default.
- W2018551404 hasConcept C185592680 @default.
- W2018551404 hasConcept C2777056448 @default.
- W2018551404 hasConcept C2779186261 @default.
- W2018551404 hasConcept C2780026642 @default.
- W2018551404 hasConcept C2780091579 @default.
- W2018551404 hasConcept C33923547 @default.
- W2018551404 hasConcept C62231903 @default.
- W2018551404 hasConcept C71924100 @default.
- W2018551404 hasConcept C86803240 @default.
- W2018551404 hasConcept C98274493 @default.
- W2018551404 hasConceptScore W2018551404C10146269 @default.
- W2018551404 hasConceptScore W2018551404C110121322 @default.
- W2018551404 hasConceptScore W2018551404C112705442 @default.
- W2018551404 hasConceptScore W2018551404C126322002 @default.
- W2018551404 hasConceptScore W2018551404C134018914 @default.
- W2018551404 hasConceptScore W2018551404C134306372 @default.
- W2018551404 hasConceptScore W2018551404C185592680 @default.
- W2018551404 hasConceptScore W2018551404C2777056448 @default.
- W2018551404 hasConceptScore W2018551404C2779186261 @default.
- W2018551404 hasConceptScore W2018551404C2780026642 @default.
- W2018551404 hasConceptScore W2018551404C2780091579 @default.
- W2018551404 hasConceptScore W2018551404C33923547 @default.
- W2018551404 hasConceptScore W2018551404C62231903 @default.
- W2018551404 hasConceptScore W2018551404C71924100 @default.
- W2018551404 hasConceptScore W2018551404C86803240 @default.
- W2018551404 hasConceptScore W2018551404C98274493 @default.
- W2018551404 hasIssue "3" @default.
- W2018551404 hasLocation W20185514041 @default.
- W2018551404 hasLocation W20185514042 @default.
- W2018551404 hasOpenAccess W2018551404 @default.
- W2018551404 hasPrimaryLocation W20185514041 @default.
- W2018551404 hasRelatedWork W1914148979 @default.
- W2018551404 hasRelatedWork W1963842437 @default.
- W2018551404 hasRelatedWork W2001333918 @default.
- W2018551404 hasRelatedWork W2071398502 @default.
- W2018551404 hasRelatedWork W2365953299 @default.
- W2018551404 hasRelatedWork W2373403320 @default.
- W2018551404 hasRelatedWork W2391021644 @default.
- W2018551404 hasRelatedWork W3142128585 @default.
- W2018551404 hasRelatedWork W2055653035 @default.
- W2018551404 hasRelatedWork W2187393073 @default.
- W2018551404 hasVolume "8" @default.
- W2018551404 isParatext "false" @default.
- W2018551404 isRetracted "false" @default.
- W2018551404 magId "2018551404" @default.
- W2018551404 workType "article" @default.